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Modular analysis of the transcriptional regulatory network of E. coli

Resendis-Antonio, Osbaldo ; Freyre-González, Julio A. ; Menchaca-Méndez, Ricardo ; Gutiérrez-Ríos, Rosa M. ; Martínez-Antonio, Agustino ; Ávila-Sánchez, Cristhian ; Collado-Vides, Julio

Trends in genetics, 2005, Vol.21 (1), p.16-20 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Título:
Modular analysis of the transcriptional regulatory network of E. coli
Autor: Resendis-Antonio, Osbaldo ; Freyre-González, Julio A. ; Menchaca-Méndez, Ricardo ; Gutiérrez-Ríos, Rosa M. ; Martínez-Antonio, Agustino ; Ávila-Sánchez, Cristhian ; Collado-Vides, Julio
Assuntos: Biological and medical sciences ; Escherichia coli ; Escherichia coli - genetics ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Bacterial ; Genetics of eukaryotes. Biological and molecular evolution ; Models, Genetic ; Molecular and cellular biology ; Molecular genetics ; Phylogeny ; Transcription, Genetic ; Transcription. Transcription factor. Splicing. Rna processing
É parte de: Trends in genetics, 2005, Vol.21 (1), p.16-20
Notas: ObjectType-Article-2
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Descrição: The transcriptional network of Escherichia coli is currently the best-understood regulatory network of a single cell. Motivated by statistical evidence, suggesting a hierarchical modular architecture in this network, we identified eight modules with well-defined physiological functions. These modules were identified by a clustering approach, using the shortest path to trace regulatory relationships across genes in the network. We report the type (feed forward and bifan) and distribution of motifs between and within modules. Feed-forward motifs tend to be embedded within modules, whereas bi-fan motifs tend to link modules, supporting the notion of a hierarchical network with defined functional modules.
Editor: Oxford: Elsevier Ltd
Idioma: Inglês

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Modular analysis of the transcriptional regulatory network of E. coli

Resendis-Antonio, Osbaldo ; Freyre-González, Julio A. ; Menchaca-Méndez, Ricardo ; Gutiérrez-Ríos, Rosa M. ; Martínez-Antonio, Agustino ; Ávila-Sánchez, Cristhian ; Collado-Vides, Julio

Oxford: Elsevier Ltd

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