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An update on vitamin D and human immunity

Hewison, Martin

Clinical endocrinology (Oxford), 2012-03, Vol.76 (3), p.315-325 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
An update on vitamin D and human immunity
Autor: Hewison, Martin
Assuntos: Adaptive Immunity - drug effects ; Adaptive Immunity - immunology ; Biological and medical sciences ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Dietary Supplements ; Endocrinopathies ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunity, Innate - drug effects ; Immunity, Innate - immunology ; Macrophages - drug effects ; Macrophages - immunology ; Macrophages - metabolism ; Medical sciences ; Models, Immunological ; Receptors, Calcitriol - immunology ; Receptors, Calcitriol - metabolism ; T-Lymphocytes - drug effects ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; Vertebrates: endocrinology ; Vitamin D ; Vitamin D - administration & dosage ; Vitamin D - immunology ; Vitamin D - metabolism
É parte de: Clinical endocrinology (Oxford), 2012-03, Vol.76 (3), p.315-325
Notas: ArticleID:CEN4261
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Descrição: Summary In the last 5 years, there has been a remarkable change in our understanding of the health benefits of vitamin D. The classical actions of vitamin D as a determinant of mineral metabolism and rachitic bone disease have been expanded to include a broader role in skeletal homoeostasis and prevalent bone disorders such as osteoporosis. However, it is the nonskeletal function of vitamin D that has attracted most attention. Although pluripotent responses to vitamin D have been recognized for many years, our new perspective on nonclassical vitamin D function stems from two more recent concepts. The first is that impaired, vitamin D status is common to many populations across the globe. This has prompted studies to explore the health impact of suboptimal circulating levels of vitamin D, with association studies linking vitamin D ‘insufficiency’ to several chronic health problems including autoimmune and cardiovascular disease, hypertension and common cancers. In support of a broader role for vitamin D in human health, studies in vitro and using animal models have highlighted immunomodulatory and anticancer effects of vitamin D that appear to depend on localized activation of vitamin D. The conclusion from these reports is that many nonclassical actions of vitamin D are independent of conventional vitamin D endocrinology and are therefore more sensitive to variations in vitamin D status. The current review summarizes these developments, with specific reference to the newly identified effects of vitamin D on the immune system, but also highlights the challenges in translating these observations to clinical practice.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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An update on vitamin D and human immunity

Hewison, Martin

Oxford, UK: Blackwell Publishing Ltd

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