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Combatting Synthetic Designer Opioids: A Conjugate Vaccine Ablates Lethal Doses of Fentanyl Class Drugs

Bremer, Paul T. ; Kimishima, Atsushi ; Schlosburg, Joel E. ; Zhou, Bin ; Collins, Karen C. ; Janda, Kim D.

Angewandte Chemie, 2016-03, Vol.128 (11), p.3836-3839 [Periódico revisado por pares]

Weinheim: Blackwell Publishing Ltd

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  • Título:
    Combatting Synthetic Designer Opioids: A Conjugate Vaccine Ablates Lethal Doses of Fentanyl Class Drugs
  • Autor: Bremer, Paul T. ; Kimishima, Atsushi ; Schlosburg, Joel E. ; Zhou, Bin ; Collins, Karen C. ; Janda, Kim D.
  • Assuntos: Ablation ; Abuse ; Analytical methods ; Antibodies ; Antikörper ; Biosensoren ; Chemistry ; Conjugates ; Cross-reactivity ; Drug abuse ; Drug addiction ; Drug dosages ; Drugs ; Fentanyl ; Fentanyle ; Immunologie ; Immunotherapy ; Konjugat-Vakzine ; Mice ; Morphine ; Narcotics ; Opioids ; Overdose ; Pain management ; Panels ; Surface plasmon resonance ; Toxicology ; Vaccines
  • É parte de: Angewandte Chemie, 2016-03, Vol.128 (11), p.3836-3839
  • Notas: National Institute on Drug Addiction - No. R21DA039634; No. F31DA037709
    istex:A78866C326F46F8600080BDBEEF6BED8B8560E8F
    ark:/67375/WNG-0Q0VMR2V-3
    ArticleID:ANGE201511654
    These authors contributed equally to this work.
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Fentanyl is an addictive prescription opioid that is over 80 times more potent than morphine. The synthetic nature of fentanyl has enabled the creation of dangerous “designer drug” analogues that escape toxicology screening, yet display comparable potency to the parent drug. Alarmingly, a large number of fatalities have been linked to overdose of fentanyl derivatives. Herein, we report an effective immunotherapy for reducing the psychoactive effects of fentanyl class drugs. A single conjugate vaccine was created that elicited high levels of antibodies with cross‐reactivity for a wide panel of fentanyl analogues. Moreover, vaccinated mice gained significant protection from lethal fentanyl doses. Lastly, a surface plasmon resonance (SPR)‐based technique was established enabling drug‐specificity profiling of antibodies derived directly from serum. Our newly developed fentanyl vaccine and analytical methods may assist in the battle against synthetic opioid abuse. Suchttherapie: Fentanyle sind suchtinduzierende Opioide und in vielen Todesfällen durch Überdosen involviert. Ein Konjugat‐Vakzin gegen Fentanyl‐ und Fentanyl‐Analoga kann Mäuse vor tödlichen Dosen schützen. Ein robuster SPR‐Biosensor wurde entwickelt, der die Affinitäten von Serumantikörpern für verschiedene Fentanyl‐Analoga im niedrigen nanomolaren Bereich erfasst.
  • Editor: Weinheim: Blackwell Publishing Ltd
  • Idioma: Inglês;Alemão
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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