skip to main content
Idioma:

Synergic control of action in levodopa-naïve Parkinson’s disease patients: I. Multi-finger interaction and coordination

de Freitas, Paulo B. ; Freitas, Sandra M. S. F. ; Reschechtko, Sasha ; Corson, Tyler ; Lewis, Mechelle M. ; Huang, Xuemei ; Latash, Mark L.

Experimental brain research, 2020-01, Vol.238 (1), p.229-245 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

Texto completo disponível

Citações Citado por
  • Título:
    Synergic control of action in levodopa-naïve Parkinson’s disease patients: I. Multi-finger interaction and coordination
  • Autor: de Freitas, Paulo B. ; Freitas, Sandra M. S. F. ; Reschechtko, Sasha ; Corson, Tyler ; Lewis, Mechelle M. ; Huang, Xuemei ; Latash, Mark L.
  • Assuntos: Biomedical and Life Sciences ; Biomedicine ; Dosage ; Drug dosages ; Levodopa ; Movement disorders ; Neurodegenerative diseases ; Neurology ; Neurosciences ; Parkinson's disease ; Research Article
  • É parte de: Experimental brain research, 2020-01, Vol.238 (1), p.229-245
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: We explored the origin of the impaired control of action stability in Parkinson’s disease (PD) by testing levodopa-naïve PD patients to disambiguate effects of PD from possible effects of long-term exposure to levodopa. Thirteen levodopa-naïve PD patients and 13 controls performed single- and multi-finger force production tasks, including producing a self-paced quick force pulse into a target. A subgroup of patients ( n  = 10) was re-tested about 1 h after the first dose of levodopa. Compared to controls, PD patients showed lower maximal forces and synergy indices stabilizing total force (reflecting the higher inter-trial variance component affecting total force). In addition, PD patients showed a trend toward shorter anticipatory synergy adjustments (a drop in the synergy index in preparation to a quick action) and larger non-motor equivalent finger force deviations. Lower maximal force, higher unintentional force production (enslaving) and higher inter-trial variance indices occurred in PD patients after one dosage of levodopa. We conclude that impairment in synergies is present in levodopa-naïve patients, mainly in indices reflecting stability (synergy index), but not agility (anticipatory synergy adjustments). A single dose of levodopa, however, did not improve synergy indices, as it did in PD patients on chronic anti-PD medication, suggesting a different mechanism of action. The results suggest that indices of force-stabilizing synergies may be used as an early behavioral sign of PD, although it may not be sensitive to acute drug effects in drug-naïve patients.
  • Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
  • Idioma: Inglês
Links
Voltar para lista de resultados
Ir para página anteriorAnterior Resultado  7 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.