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Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals

Vázquez-Castellanos, J F ; Serrano-Villar, S ; Latorre, A ; Artacho, A ; Ferrús, M L ; Madrid, N ; Vallejo, A ; Sainz, T ; Martínez-Botas, J ; Ferrando-Martínez, S ; Vera, M ; Dronda, F ; Leal, M ; Del Romero, J ; Moreno, S ; Estrada, V ; Gosalbes, M J ; Moya, A

Mucosal immunology, 2015-07, Vol.8 (4), p.760-772 [Periódico revisado por pares]

United States: Nature Publishing Group

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Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals
Autor: Vázquez-Castellanos, J F ; Serrano-Villar, S ; Latorre, A ; Artacho, A ; Ferrús, M L ; Madrid, N ; Vallejo, A ; Sainz, T ; Martínez-Botas, J ; Ferrando-Martínez, S ; Vera, M ; Dronda, F ; Leal, M ; Del Romero, J ; Moreno, S ; Estrada, V ; Gosalbes, M J ; Moya, A
Assuntos: Adaptive Immunity ; Antiretroviral Therapy, Highly Active ; Bayes Theorem ; Biodiversity ; Case-Control Studies ; Cluster Analysis ; Disease Progression ; Gastrointestinal Microbiome ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV Infections - metabolism ; HIV Infections - microbiology ; HIV-1 - immunology ; Humans ; Immunity, Innate ; Markov Chains ; Metabolome ; Metabolomics ; Metagenome ; RNA, Ribosomal, 16S
É parte de: Mucosal immunology, 2015-07, Vol.8 (4), p.760-772
Descrição: Altered interplay between gut mucosa and microbiota during treated HIV infection may possibly contribute to increased bacterial translocation and chronic immune activation, both of which are predictors of morbidity and mortality. Although a dysbiotic gut microbiota has recently been reported in HIV+ individuals, the metagenome gene pool associated with HIV infection remains unknown. The aim of this study is to characterize the functional gene content of gut microbiota in HIV+ patients and to define the metabolic pathways of this bacterial community, which is potentially associated with immune dysfunction. We determined systemic markers of innate and adaptive immunity in a cohort of HIV-infected individuals on successful antiretroviral therapy without comorbidities and in healthy non-HIV-infected subjects. Metagenome sequencing revealed an altered functional profile, with enrichment of the genes involved in various pathogenic processes, lipopolysaccharide biosynthesis, bacterial translocation, and other inflammatory pathways. In contrast, we observed depletion of genes involved in amino acid metabolism and energy processes. Bayesian networks showed significant interactions between the bacterial community, their altered metabolic pathways, and systemic markers of immune dysfunction. This study reveals altered metabolic activity of microbiota and provides novel insight into the potential host-microbiota interactions driving the sustained inflammatory state in successfully treated HIV-infected patients.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals

Vázquez-Castellanos, J F ; Serrano-Villar, S ; Latorre, A ; Artacho, A ; Ferrús, M L ; Madrid, N ; Vallejo, A ; Sainz, T ; Martínez-Botas, J ; Ferrando-Martínez, S ; Vera, M ; Dronda, F ; Leal, M ; Del Romero, J ; Moreno, S ; Estrada, V ; Gosalbes, M J ; Moya, A

United States: Nature Publishing Group

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