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Do hyperandrogenic women with normal menses have polycystic ovary syndrome?

Carmina, Enrico ; Lobo, Rogerio A

Fertility and sterility, 1999-02, Vol.71 (2), p.319-322 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Do hyperandrogenic women with normal menses have polycystic ovary syndrome?
Autor: Carmina, Enrico ; Lobo, Rogerio A
Assuntos: 17-alpha-Hydroxyprogesterone - metabolism ; Adult ; Biological and medical sciences ; Case-Control Studies ; eumenorrhea ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; hyperandrogenism ; Hyperandrogenism - etiology ; Medical sciences ; Menstrual Cycle - physiology ; Ovary - pathology ; Ovulation - physiology ; PCOS ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - epidemiology ; Polycystic Ovary Syndrome - pathology ; Prevalence ; Prospective Studies ; Receptors, LHRH - agonists ; Tumors
É parte de: Fertility and sterility, 1999-02, Vol.71 (2), p.319-322
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Objective: To determine the prevalence of polycystic ovary syndrome (PCOS) among hyperandrogenic women who report normal menses. Design: Prospective observational study. Setting: Academic practice in reproductive endocrinology. Patient(s): Fifty-eight consecutively seen new patients with hyperandrogenism who reported normal menses. Intervention(s): Ovulatory status was assessed with timed serum progesterone measurements. The following tests also were carried out: vaginal ultrasound examination; measurement of the ovarian response of 17-hydroxyprogesterone (17-OHP) after the administration of leuprolide acetate, 1 mg SC; and determination of fasting serum LH, FSH, E 2, 17-OHP, insulin, and androgen levels. Main Outcome Measure(s): Determination of ovulatory status, polycystic appearance of ovaries, and increased response of 17-OHP to leuprolide acetate. Result(s): Twelve (20.7%) of the hyperandrogenic women were anovulatory and met the usual criteria for the diagnosis of PCOS. The ovulatory patients had lower serum total and unbound testosterone levels. Thirty-one (53.4%) of the ovulatory women had polycystic ovaries on ultrasound examination and/or an increased 17-OHP response to leuprolide acetate, suggesting the diagnosis of PCOS despite the presence of ovulation. Considering both the anovulatory and ovulatory patients, 74% of the hyperandrogenic women studied could have PCOS. Conclusion(s): The data suggest that most (74%) hyperandrogenic women who report normal menses have evidence for the diagnosis of PCOS.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Do hyperandrogenic women with normal menses have polycystic ovary syndrome?

Carmina, Enrico ; Lobo, Rogerio A

New York, NY: Elsevier Inc

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