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Effect of Des-Tyrosine-γ-Endorphin in Tardive Dyskinesia
Casey, Daniel E ; Korsgaard, Soren ; Gerlach, Jes ; Jørgensen, Aage ; Simmelsgaard, Hans
Archives of general psychiatry, 1981-02, Vol.38 (2), p.158-160
United States: American Medical Association
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Título:
Effect of Des-Tyrosine-γ-Endorphin in Tardive Dyskinesia
Autor:
Casey, Daniel E
;
Korsgaard, Soren
;
Gerlach, Jes
;
Jørgensen, Aage
;
Simmelsgaard, Hans
Assuntos:
Blinking - drug effects
;
Clinical Trials as Topic
;
Double-Blind Method
;
Dyskinesia, Drug-Induced - physiopathology
;
Endorphins - pharmacology
;
Endorphins - therapeutic use
;
Female
;
Humans
;
Male
;
Parkinson Disease, Secondary - physiopathology
;
Peptide Fragments - pharmacology
;
Peptide Fragments - therapeutic use
;
Placebos
;
Receptors, Dopamine - drug effects
;
Receptors, Dopamine - physiology
;
Schizophrenia - drug therapy
;
Schizophrenia - physiopathology
É parte de:
Archives of general psychiatry, 1981-02, Vol.38 (2), p.158-160
Descrição:
• The endorphin neuropeptides may have neuroleptic-like effects on dopamine function and may be antischizophrenic. Ten chronic psychotic patients with neuroleptic-induced tardive dyskinesia and parkinsonism received placebo and des-tyrosineγ-endorphin (DTγE). Drug effects on movement disorders and eye-blinking rates were assessed by blind evaluations of randomly sequenced videotapes made during standardized examinations before and 30, 60, and 120 minutes after each injection and at 24 hours postinjection on days of consecutive treatment. Changes in schizophrenic symptoms were evaluated openly with the schizophrenia subscale of the Comprehensive Psychiatric Rating Scale. There were no significant effects of DTγE on any parameter and no side effects. This suggests that DTγE, within the tested dose range, does not influence the pathophysiology of neuroleptic-induced dyskinesias or chronic schizophrenia or have neuroleptic properties. However, DTγE is well tolerated and should be tested with higher doses during prolonged treatment.
Editor:
United States: American Medical Association
Idioma:
Inglês
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