skip to main content
Idioma:

Ambulation capacity, age, immunosuppression, and mechanical ventilation are risk factors of in-hospital death in severe COVID-19: a cohort study

Silva, Erika Christina Gouveia E; Schmitt, Ana Carolina Basso; Godoy, Caroline Gil De; Gambeta, Amislaine Cristina; Carvalho, Celso Ricardo Fernandes De; Fu, Carolina; Tanaka, Clarice; Toufen Junior, Carlos; Carvalho, Carlos Roberto Ribeiro De; Pompeu, Jos�� Eduardo

Clinics; v. 77 (2022); 100075

Hospital das Cl��nicas, Faculdade de Medicina, Universidade de S��o Paulo 2022-07-04

Acesso online

  • Título:
    Ambulation capacity, age, immunosuppression, and mechanical ventilation are risk factors of in-hospital death in severe COVID-19: a cohort study
  • Autor: Silva, Erika Christina Gouveia E; Schmitt, Ana Carolina Basso; Godoy, Caroline Gil De; Gambeta, Amislaine Cristina; Carvalho, Celso Ricardo Fernandes De; Fu, Carolina; Tanaka, Clarice; Toufen Junior, Carlos; Carvalho, Carlos Roberto Ribeiro De; Pompeu, Jos�� Eduardo
  • Assuntos: Covid-19; Adult; Older Adult; Hospitalisation; Ambulation Capacity
  • É parte de: Clinics; v. 77 (2022); 100075
  • Descrição: Importance: Despite ambulation capacity being associated with a decreased level of physical activity and survival may be influenced by the functional capacity, studies have not addressed the association between ambulation capacity and death in patients hospitalized by COVID-19.Objective: To verify the functional, clinical, and sociodemographic risk factors associated with in-hospital death in individuals with severe COVID-19.Methods: It is a cohort retrospective study performed at a large tertiary hospital. Patients 18 years of age or more, of both sexes, hospitalized due to severe COVID-19 were included. Cases with dubious medical records and/or missing essential data were excluded. Patients were classified according to their ambulation capacity before the COVID-19 infection. Information regarding sociodemographic characteristics, in-hospital death, total hospital stays, Intensive Care Unit (ICU) stays, and the necessity of Mechanical Ventilation (MV) were collected from medical records and registered in a RedCap database. Multiple logistic regression analysis was used to identify possible factors associated with the in-hospital death rate.Results: Data from 1110 participants were included in the statistical analysis. The median age of the patients was 57 (46���66) years, 58.42% (n = 590) were male, and 61.73% (n = 602) were brown or black. The case fatality rate during hospitalization was 36.0% (n = 363). In-hospital death was associated with ambulation capacity; dependent ambulators (OR = 2.3; CI 95% = 1.2���4.4) and non-functional ambulation (OR = 1.9; CI 95% = 1.1���3.3), age [older adults (OR = 3.0; CI 95% = 1.9���4.), ICU stays (OR = 1.4; CI 95% = 1.2���1.4), immunosuppression (OR = 5.5 CI 95% = 2.3���13.5) and mechanical ventilation (OR = 27.5; CI 95% = 12.0���62.9).Conclusion and relevance: Decreased ambulation capacity, age, length of ICU stay, immunosuppression, and mechanical ventilation was associated with a high risk of in-hospital death due to COVID-19.
  • Títulos relacionados: https://www.revistas.usp.br/clinics/article/view/213515/195613
  • Editor: Hospital das Cl��nicas, Faculdade de Medicina, Universidade de S��o Paulo
  • Data de criação/publicação: 2022-07-04
  • Formato: Adobe PDF
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.