Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial

• Autor: Teerlink, John R, Prof ; Cotter, Gad, MD ; Davison, Beth A, PhD ; Felker, G Michael, MD ; Filippatos, Gerasimos, Prof ; Greenberg, Barry H, Prof ; Ponikowski, Piotr, Prof ; Unemori, Elaine, PhD ; Voors, Adriaan A, Prof ; Adams, Kirkwood F, MD ; Dorobantu, Maria I, Prof ; Grinfeld, Liliana R, MD ; Jondeau, Guillaume, Prof ; Marmor, Alon, Prof ; Masip, Josep, Prof ; Pang, Peter S, MD ; Werdan, Karl, Prof ; Teichman, Sam L, MD ; Trapani, Angelo, PhD ; Bush, Christopher A, PhD ; Saini, Rajnish, MD ; Schumacher, Christoph, PhD ; Severin, Thomas M, MD ; Metra, Marco, Prof
• Assuntos: Acute coronary syndromes ; Acute Disease ; Aged ; Biological and medical sciences ; brain ; Cardiology. Vascular system ; chest ; death ; Double-Blind Method ; Drug therapy ; drugs ; Dyspnea - drug therapy ; Dyspnea - etiology ; Female ; General aspects ; Heart ; Heart attacks ; Heart failure ; Heart Failure - complications ; Heart Failure - drug therapy ; Heart Failure - mortality ; Heart Failure - physiopathology ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; human resources ; Humans ; Indexing in process ; Internal Medicine ; intravenous injection ; Length of Stay ; Male ; Medical sciences ; Mortality ; natriuretic peptides ; Nitrates ; Patients ; radiography ; Recombinant Proteins - therapeutic use ; Relaxin - therapeutic use ; renal failure ; Survival Rate ; systolic blood pressure
• É parte de: The Lancet (British edition), 2013-01, Vol.381 (9860), p.29-39
• Notas: http://dx.doi.org/10.1016/S0140-6736(12)61855-8
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• Descrição: Summary Background Serelaxin, recombinant human relaxin-2, is a vasoactive peptide hormone with many biological and haemodynamic effects. In a pilot study, serelaxin was safe and well tolerated with positive clinical outcome signals in patients with acute heart failure. The RELAX-AHF trial tested the hypothesis that serelaxin-treated patients would have greater dyspnoea relief compared with patients treated with standard care and placebo. Methods RELAX-AHF was an international, double-blind, placebo-controlled trial, enrolling patients admitted to hospital for acute heart failure who were randomly assigned (1:1) via a central randomisation scheme blocked by study centre to standard care plus 48-h intravenous infusions of placebo or serelaxin (30 μg/kg per day) within 16 h from presentation. All patients had dyspnoea, congestion on chest radiograph, increased brain natriuretic peptide (BNP) or N-terminal prohormone of BNP, mild-to-moderate renal insufficiency, and systolic blood pressure greater than 125 mm Hg. Patients, personnel administering study drug, and those undertaking study-related assessments were masked to treatment assignment. The primary endpoints evaluating dyspnoea improvement were change from baseline in the visual analogue scale area under the curve (VAS AUC) to day 5 and the proportion of patients with moderate or marked dyspnoea improvement measured by Likert scale during the first 24 h, both analysed by intention to treat. This trial is registered at ClinicalTrials.gov , NCT00520806. Findings 1161 patients were randomly assigned to serelaxin (n=581) or placebo (n=580). Serelaxin improved the VAS AUC primary dyspnoea endpoint (448 mm × h, 95% CI 120–775; p=0·007) compared with placebo, but had no significant effect on the other primary endpoint (Likert scale; placebo, 150 patients [26%]; serelaxin, 156 [27%]; p=0·70). No significant effects were recorded for the secondary endpoints of cardiovascular death or readmission to hospital for heart failure or renal failure (placebo, 75 events [60-day Kaplan-Meier estimate, 13·0%]; serelaxin, 76 events [13·2%]; hazard ratio [HR] 1·02 [0·74–1·41], p=0·89] or days alive out of the hospital up to day 60 (placebo, 47·7 [SD 12·1] days; serelaxin, 48·3 [11·6]; p=0·37). Serelaxin treatment was associated with significant reductions of other prespecified additional endpoints, including fewer deaths at day 180 (placebo, 65 deaths; serelaxin, 42; HR 0·63, 95% CI 0·42–0·93; p=0·019). Interpretation Treatment of acute heart failure with serelaxin was associated with dyspnoea relief and improvement in other clinical outcomes, but had no effect on readmission to hospital. Serelaxin treatment was well tolerated and safe, supported by the reduced 180-day mortality. Funding Corthera, a Novartis affiliate company.
  
• Editor: Kidlington: Elsevier Ltd
  
• Idioma: Inglês