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Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: A study of cases from an Internet-based registry

Agero, Anna Liza C. ; Benvenuto-Andrade, Cristiane ; Dusza, Stephen W. ; Halpern, Allan C. ; Marghoob, Ashfaq A.

Journal of the American Academy of Dermatology, 2005-12, Vol.53 (6), p.959-965 [Periódico revisado por pares]

New York, NY: Mosby, Inc

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Título:
Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: A study of cases from an Internet-based registry
Autor: Agero, Anna Liza C. ; Benvenuto-Andrade, Cristiane ; Dusza, Stephen W. ; Halpern, Allan C. ; Marghoob, Ashfaq A.
Assuntos: Adolescent ; Adult ; Biological and medical sciences ; Child ; Child, Preschool ; Dermatology ; Female ; Humans ; Infant ; Infant, Newborn ; Internet ; Male ; Medical sciences ; Melanosis - complications ; Melanosis - diagnosis ; Middle Aged ; Neurocutaneous Syndromes - complications ; Neurocutaneous Syndromes - diagnosis ; Nevus, Pigmented - complications ; Pigmentary diseases of the skin ; Registries ; Skin Neoplasms - complications ; Tumors of the skin and soft tissue. Premalignant lesions
É parte de: Journal of the American Academy of Dermatology, 2005-12, Vol.53 (6), p.959-965
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Recent retrospective studies using magnetic resonance imaging (MRI) to screen for neurocutaneous melanocytosis (NCM) among neurologically asymptomatic children with large congenital melanocytic nevi (LCMN) report high prevalence (23-30%) of asymptomatic NCM. We sought to determine prevalence of asymptomatic NCM, and current application of MRI as a screening tool. Patients with LCMN from an Internet-based registry answered a questionnaire regarding NCM status. Of 379 patients with LCMN, 26 reportedly had NCM, with 17 reporting neurologic symptoms. Of 186 patients undergoing MRI, 9 reported abnormal findings without neurologic symptoms (4.8%); 80% had LCMN on the posterior axis, whereas 55% had more than 20 satellite nevi. Study data rely on the registry members' self-reported findings and are limited by lack of independent data verification. Asymptomatic NCM (determined by MRI) may not be common, with much lower prevalence (4.8%) than previously reported. MRI is widely used for screening patients at risk for NCM, such as patients with LCMN involving the posterior axis and greater than 20 satellite nevi.
Editor: New York, NY: Mosby, Inc
Idioma: Inglês

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Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: A study of cases from an Internet-based registry

Agero, Anna Liza C. ; Benvenuto-Andrade, Cristiane ; Dusza, Stephen W. ; Halpern, Allan C. ; Marghoob, Ashfaq A.

New York, NY: Mosby, Inc

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