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Distribution of Saponins in the Sea Cucumber Holothuria lessoni ; the Body Wall Versus the Viscera, and Their Biological Activities

Bahrami, Yadollah ; Zhang, Wei ; M M Franco, Christopher

Marine drugs, 2018-11, Vol.16 (11), p.423 [Revista revisada por pares]

Switzerland: MDPI AG

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Distribution of Saponins in the Sea Cucumber Holothuria lessoni ; the Body Wall Versus the Viscera, and Their Biological Activities
Autor: Bahrami, Yadollah ; Zhang, Wei ; M M Franco, Christopher
Materias: Ageing ; Aging ; Aging (natural) ; Alzheimers disease ; Animals ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; antibacterial ; Antibacterial activity ; Antibiotics ; Anticancer properties ; antifungal ; Antifungal Agents - chemistry ; Antifungal Agents - isolation & purification ; Antifungal Agents - pharmacology ; antioxidant ; Arthritis ; Bioactive compounds ; Biological Products - isolation & purification ; Biological Products - pharmacology ; Body wall ; Bone marrow ; Chromatography ; Chromatography, High Pressure Liquid - methods ; Congeners ; Cosmeceuticals ; Cosmetics ; Distribution ; ESI ; Ethanol ; Functional foods & nutraceuticals ; Fungi ; Fungi - drug effects ; Fungicides ; Glucose ; Glycosides ; Glycosides - chemistry ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Hematopoiesis ; Holothuria ; Holothuria - chemistry ; Holothuroidea ; HPLC ; Hypertension ; Hyperuricemia ; Hypolipidemic activity ; Isobutanol ; LC-MS ; Liquid-liquid extraction ; MALDI ; marine ginseng ; marine invertebrate ; Marine invertebrates ; Mass spectrometry ; Medicine ; Metabolites ; Microbial Sensitivity Tests ; Molecular Structure ; Molecular weight ; natural products ; NMR ; Nuclear magnetic resonance ; Pain ; saponin ; Saponins ; Saponins - chemistry ; Saponins - isolation & purification ; Saponins - pharmacology ; Scientific imaging ; sea cucumber ; Seafood ; Secondary metabolites ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods ; Staphylococcus aureus - drug effects ; structure elucidation ; Tandem Mass Spectrometry - methods ; triterpene glycosides ; Triterpenes - chemistry ; Triterpenes - isolation & purification ; Triterpenes - pharmacology ; Tumors ; Viscera ; Viscera - chemistry ; Wound healing
Es parte de: Marine drugs, 2018-11, Vol.16 (11), p.423
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descripción: Sea cucumbers are an important ingredient of traditional folk medicine in many Asian countries, which are well-known for their medicinal, nutraceutical, and food values due to producing an impressive range of distinctive natural bioactive compounds. Triterpene glycosides are the most abundant and prime secondary metabolites reported in this species. They possess numerous biological activities ranging from anti-tumour, wound healing, hypolipidemia, pain relieving, the improvement of nonalcoholic fatty livers, anti-hyperuricemia, the induction of bone marrow hematopoiesis, anti-hypertension, and cosmetics and anti-ageing properties. This study was designed to purify and elucidate the structure of saponin contents of the body wall of sea cucumber and to compare the distribution of saponins of the body wall with that of the viscera. The body wall was extracted with 70% ethanol, and purified by a liquid-liquid partition chromatography, followed by isobutanol extraction. A high-performance centrifugal partition chromatography (HPCPC) was conducted on the saponin-enriched mixture to obtain saponins with a high purity. The resultant purified saponins were analyzed using MALDI-MS/MS and ESI-MS/MS. The integrated and hyphenated MS and HPCPC analyses revealed the presence of 89 saponin congeners, including 35 new and 54 known saponins, in the body wall in which the majority of glycosides are of the holostane type. As a result, and in conjunction with existing literature, the structure of four novel acetylated saponins, namely lessoniosides H, I, J, and K were characterized. The identified triterpene glycosides showed potent antifungal activities against tested fungi, but had no antibacterial effects on the bacterium . The presence of a wide range of saponins with potential applications is promising for cosmeceutical, medicinal, and pharmaceutical products to improve human health.
Editor: Switzerland: MDPI AG
Idioma: Inglés

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Distribution of Saponins in the Sea Cucumber Holothuria lessoni ; the Body Wall Versus the Viscera, and Their Biological Activities

Bahrami, Yadollah ; Zhang, Wei ; M M Franco, Christopher

Switzerland: MDPI AG

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