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Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

Guarente, Leonard

Cell, 2008-01, Vol.132 (2), p.171-176 [Periódico revisado por pares]

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Título:
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
Autor: Guarente, Leonard
Assuntos: Aging ; Animals ; Caloric Restriction ; Humans ; Mitochondria - physiology ; Models, Biological ; Sirtuins
É parte de: Cell, 2008-01, Vol.132 (2), p.171-176
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Correspondence: leng@mit.edu
Descrição: Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.
Editor: United States: Elsevier Inc
Idioma: Inglês

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