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Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog

Davison, Angus ; McDowell, Gary S. ; Holden, Jennifer M. ; Johnson, Harriet F. ; Koutsovoulos, Georgios D. ; Liu, M. Maureen ; Hulpiau, Paco ; Van Roy, Frans ; Wade, Christopher M. ; Banerjee, Ruby ; Yang, Fengtang ; Chiba, Satoshi ; Davey, John W. ; Jackson, Daniel J. ; Levin, Michael ; Blaxter, Mark L.

Current biology, 2016-03, Vol.26 (5), p.654-660 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog
Autor: Davison, Angus ; McDowell, Gary S. ; Holden, Jennifer M. ; Johnson, Harriet F. ; Koutsovoulos, Georgios D. ; Liu, M. Maureen ; Hulpiau, Paco ; Van Roy, Frans ; Wade, Christopher M. ; Banerjee, Ruby ; Yang, Fengtang ; Chiba, Satoshi ; Davey, John W. ; Jackson, Daniel J. ; Levin, Michael ; Blaxter, Mark L.
Assuntos: Animals ; Body Patterning ; Fetal Proteins - genetics ; Fetal Proteins - metabolism ; Formins ; Lymnaea - embryology ; Lymnaea - genetics ; Lymnaea - metabolism ; Microfilament Proteins - genetics ; Microfilament Proteins - metabolism ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Phenotype ; Signal Transduction ; Xenopus laevis - embryology ; Xenopus laevis - genetics ; Xenopus laevis - metabolism
É parte de: Current biology, 2016-03, Vol.26 (5), p.654-660
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Present address: Warwick Medical School, The University of Warwick, Coventry CV4 7AL, UK
Present address: Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Descrição: While components of the pathway that establishes left-right asymmetry have been identified in diverse animals, from vertebrates to flies, it is striking that the genes involved in the first symmetry-breaking step remain wholly unknown in the most obviously chiral animals, the gastropod snails. Previously, research on snails was used to show that left-right signaling of Nodal, downstream of symmetry breaking, may be an ancestral feature of the Bilateria [1, 2]. Here, we report that a disabling mutation in one copy of a tandemly duplicated, diaphanous-related formin is perfectly associated with symmetry breaking in the pond snail. This is supported by the observation that an anti-formin drug treatment converts dextral snail embryos to a sinistral phenocopy, and in frogs, drug inhibition or overexpression by microinjection of formin has a chirality-randomizing effect in early (pre-cilia) embryos. Contrary to expectations based on existing models [3–5], we discovered asymmetric gene expression in 2- and 4-cell snail embryos, preceding morphological asymmetry. As the formin-actin filament has been shown to be part of an asymmetry-breaking switch in vitro [6, 7], together these results are consistent with the view that animals with diverse body plans may derive their asymmetries from the same intracellular chiral elements [8]. •Animals tend to be outwardly symmetric but internally are asymmetric•Unlike other animals, snails show inherited variation in asymmetry•We found that both snails and frogs use a common gene to define left and right•Asymmetry is probably an ancient and conserved property of cells and animals Davison et al. have discovered a cell scaffolding protein in snails and frogs that controls body asymmetry, either the direction a snail shell coils, or whether a frog heart is placed to the left or right. Body asymmetry in animals, including humans, likely arises from a highly conserved, intrinsic asymmetry of the cell.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog

England: Elsevier Ltd

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