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Investigation of Citrinin and Pigment Biosynthesis Mechanisms in Monascus purpureus by Transcriptomic Analysis

Liang, Bin ; Du, Xin-Jun ; Li, Ping ; Sun, Chan-Chan ; Wang, Shuo

Frontiers in microbiology, 2018-06, Vol.9, p.1374-1374 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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  • Título:
    Investigation of Citrinin and Pigment Biosynthesis Mechanisms in Monascus purpureus by Transcriptomic Analysis
  • Autor: Liang, Bin ; Du, Xin-Jun ; Li, Ping ; Sun, Chan-Chan ; Wang, Shuo
  • Assuntos: citrinin ; Microbiology ; Monascus purpureus ; pigment ; solid-state fermentation ; transcriptomic analysis
  • É parte de: Frontiers in microbiology, 2018-06, Vol.9, p.1374-1374
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Reviewed by: Jiangxin Wang, Shenzhen University, China; Alejandro Sanchez-Flores, Universidad Nacional Autónoma de México, Mexico
    This article was submitted to Food Microbiology, a section of the journal Frontiers in Microbiology
    Edited by: Florence Abram, National University of Ireland Galway, Ireland
  • Descrição: YY-1 is widely used in food colorant production in China. Our previous study clearly illustrated the whole-genome data for YY-1 and provided useful insight into evolutionary research and industrial applications. However, the presence of citrinin, which has nephrotoxic, hepatotoxic, and carcinogenic activities, has attracted attention to the safety of products. In an effort to reduce the harmful effects of citrinin in related products, a random mutant of YY-1 with low citrinin production (designated as "winter") was obtained in this study. To analyze the biosynthesis and regulation mechanisms of pigment and citrinin, a transcriptomic analysis of the YY-1 and winter strains was performed. Comparative transcriptomic analysis reveals , the essential gene for citrinin synthesis, showed a low expression level in YY-1 and winter, which suggested there might be isoenzymes in YY-1 that were responsible for the citrinin synthesis during evolution. In addition, changes in transcription factor expression may also influence the network regulating the citrinin synthesis pathway in . Moreover, the yields of pigments produced by the winter mutant were significantly increased. Repressing the central carbon metabolism and improving the acetyl-CoA pool can contribute to a high pigment yield, and enhanced NADPH regeneration can also lead to the metabolic flux of pigment production in . Investigations into the biosynthesis and regulation of citrinin and pigment production in will enhance our knowledge of the mechanisms behind the biosynthesis of fungal secondary metabolites.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
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