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Synergy of Dietary Quercetin and Vitamin E Improves Cecal Microbiota and Its Metabolite Profile in Aged Breeder Hens

Amevor, Felix Kwame ; Cui, Zhifu ; Du, Xiaxia ; Feng, Jing ; Shu, Gang ; Ning, Zifan ; Xu, Dan ; Deng, Xun ; Song, Weizhen ; Wu, Youhao ; Cao, Xueqing ; Wei, Shuo ; He, Juan ; Kong, Fanli ; Du, Xiaohui ; Tian, Yaofu ; Karikari, Benjamin ; Li, Diyan ; Wang, Yan ; Zhang, Yao ; Zhu, Qing ; Zhao, Xiaoling

Frontiers in microbiology, 2022-05, Vol.13, p.851459-851459 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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  • Título:
    Synergy of Dietary Quercetin and Vitamin E Improves Cecal Microbiota and Its Metabolite Profile in Aged Breeder Hens
  • Autor: Amevor, Felix Kwame ; Cui, Zhifu ; Du, Xiaxia ; Feng, Jing ; Shu, Gang ; Ning, Zifan ; Xu, Dan ; Deng, Xun ; Song, Weizhen ; Wu, Youhao ; Cao, Xueqing ; Wei, Shuo ; He, Juan ; Kong, Fanli ; Du, Xiaohui ; Tian, Yaofu ; Karikari, Benjamin ; Li, Diyan ; Wang, Yan ; Zhang, Yao ; Zhu, Qing ; Zhao, Xiaoling
  • Assuntos: aged breeder hens ; dietary quercetin ; gut microbiota ; metabolite ; Microbiology ; vitamin E
  • É parte de: Frontiers in microbiology, 2022-05, Vol.13, p.851459-851459
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Edited by: Qixiao Zhai, Jiangnan University, China
    This article was submitted to Microbial Immunology, a section of the journal Frontiers in Microbiology
    Reviewed by: Zhaolai Dai, China Agricultural University, China; Qian Jiang, Hunan Agricultural University, China
  • Descrição: In the present study, the synergistic effects of quercetin (Q) and vitamin E (E) on cecal microbiota composition and function, as well as the microbial metabolic profile in aged breeder hens were investigated. A total of 400 (65 weeks old) Tianfu breeder hens were randomly allotted to four experimental groups (four replicates per group). The birds were fed diets containing quercetin at 0.4 g/kg, vitamin E (0.2 g/kg), quercetin and vitamin E (QE; 0.4 g/kg and 0.2 g/kg), and a basal diet for a period of 10 wks. After the 10 week experimental period, the cecal contents of 8 aged breeder hens per group were sampled aseptically and subjected to high-throughput 16S rRNA gene sequencing and untargeted metabolomic analysis. The results showed that the relative abundances of phyla , and were the most prominent among all the dietary groups. Compared to the control group, the relative abundance of the families , , and were enriched in the QE group; and and were enriched in the Q group, whereas those of and were enriched in the E group compared to the control group. Untargeted metabolomics analyses revealed that Q, E, and QE modified the abundance of several metabolites in prominent pathways including ubiquinone and other terpenoid-quinone biosynthesis, regulation of actin cytoskeleton, insulin secretion, pancreatic secretion, nicotine addiction, and metabolism of xenobiotics by cytochrome P450. Furthermore, key cecal microbiota, significantly correlated with important metabolites, ( )-equol positively correlated with and in E_vs_C, and negatively correlated with , and but, a contrary trend was observed with in QE_vs_C. This study establishes that the synergy of quercetin and vitamin E alters the cecal microbial composition and metabolite profile in aged breeder hens, which lays a foundation for chicken improvement programs.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
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