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Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

Li, Ting ; Rooij, Daan ; Roth Mota, Nina ; Buitelaar, Jan K. ; Hoogman, Martine ; Arias Vasquez, Alejandro ; Franke, Barbara ; Ambrosino, Sara ; Banaschewski, Tobias ; Bandeira, Cibele E. ; Bau, Claiton H.D. ; Baumeister, Sarah ; Baur‐Streubel, Ramona ; Bellgrove, Mark A. ; Biederman, Joseph ; Bramati, Ivanei E. ; Berm, Silvia ; Busatto, Geraldo F. ; Calvo, Anna ; Castellanos, Francisco X. ; Chantiluke, Kaylita C. ; Christakou, Anastasia ; Coghill, David ; Conzelmann, Annette ; Cupertino, Renata B. ; Zeeuw, Parick ; Durston, Sarah ; Earl, Eric A. ; Epstein, Jeffery N. ; Fallgatter, Andreas J. ; Fair, Damien A. ; Faraone, Stephen V. ; Frodl, Thomas ; Gabel, Matt C. ; Gogberashvili, Tinatin ; Grevet, Eugenio H. ; Haavik, Jan ; Hartman, Catharina A. ; Heslenfeld, Dirk J. ; Hoekstra, Pieter J. ; Høvik, Marie F. ; Jahanshad, Neda ; Karkashadze, Georgii ; Kelly, Clare ; Kohls, Gregor ; Konrad, Kerstin ; Kuntsi, Jonna ; Lazaro, Luisa ; Lera‐Miguel, Sara ; Lesch, Klaus‐Peter ; Louza, Mario R. ; Lundervold, Astri J. ; McCarthy, Hazel ; Nicolau, Rosa ; Nigg, Joel T. ; O'Gorman Tuura, Ruth L. ; Oosterlaan, Jaap ; Oranje, Bob ; Paloyelis, Yannis ; Pauli, Paul ; Plessen, Kerstin J. ; Ramos‐Quiroga, J. Antoni ; Reif, Andreas ; Reneman, Liesbeth ; Rosa, Pedro G.P. ; Rubia, Katya ; Schrantee, Anouk ; Schweren, Lizanne J.S. ; Seitz, Jochen ; Shaw, Philip ; Silk, Tim J. ; Skokauskas, Norbert ; Carlos Soliva Vila, Juan ; Soloveva, Anastasiia ; Stevens, Michael C. ; Sudre, Gustavo ; Tamm, Leanne ; Thompson, Paul M. ; Tovar‐Moll, Fernanda ; Erp, Theo GM ; Vance, Alasdair ; Vilarroya, Oscar ; Vives‐Gilabert, Yolanda ; Walitza, Susanne ; Yoncheva, Yuliya N. ; Zanetti, Marcus V. ; Ziegler, Georg C. ; Anikin, Anatoly ; Asherson, Philip ; Baranov, Alexandr ; Chaim‐Avanicini, Tiffany ; Dale, Anders M. ; Doyle, Alysa E. ; Jernigan, Terry ; Kapilushniy, Dmitry ; Mehta, Mitul ; Namazova‐Baranova, Leyla ; Novotny, Stephanie E. ; Oberwelland Weiss, Eileen ; Schwarz, Lena

Journal of child psychology and psychiatry, 2021-09, Vol.62 (9), p.1140-1149 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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Título:
Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes
Autor: Li, Ting ; Rooij, Daan ; Roth Mota, Nina ; Buitelaar, Jan K. ; Hoogman, Martine ; Arias Vasquez, Alejandro ; Franke, Barbara ; Ambrosino, Sara ; Banaschewski, Tobias ; Bandeira, Cibele E. ; Bau, Claiton H.D. ; Baumeister, Sarah ; Baur‐Streubel, Ramona ; Bellgrove, Mark A. ; Biederman, Joseph ; Bramati, Ivanei E. ; Berm, Silvia ; Busatto, Geraldo F. ; Calvo, Anna ; Castellanos, Francisco X. ; Chantiluke, Kaylita C. ; Christakou, Anastasia ; Coghill, David ; Conzelmann, Annette ; Cupertino, Renata B. ; Zeeuw, Parick ; Durston, Sarah ; Earl, Eric A. ; Epstein, Jeffery N. ; Fallgatter, Andreas J. ; Fair, Damien A. ; Faraone, Stephen V. ; Frodl, Thomas ; Gabel, Matt C. ; Gogberashvili, Tinatin ; Grevet, Eugenio H. ; Haavik, Jan ; Hartman, Catharina A. ; Heslenfeld, Dirk J. ; Hoekstra, Pieter J. ; Høvik, Marie F. ; Jahanshad, Neda ; Karkashadze, Georgii ; Kelly, Clare ; Kohls, Gregor ; Konrad, Kerstin ; Kuntsi, Jonna ; Lazaro, Luisa ; Lera‐Miguel, Sara ; Lesch, Klaus‐Peter ; Louza, Mario R. ; Lundervold, Astri J. ; McCarthy, Hazel ; Nicolau, Rosa ; Nigg, Joel T. ; O'Gorman Tuura, Ruth L. ; Oosterlaan, Jaap ; Oranje, Bob ; Paloyelis, Yannis ; Pauli, Paul ; Plessen, Kerstin J. ; Ramos‐Quiroga, J. Antoni ; Reif, Andreas ; Reneman, Liesbeth ; Rosa, Pedro G.P. ; Rubia, Katya ; Schrantee, Anouk ; Schweren, Lizanne J.S. ; Seitz, Jochen ; Shaw, Philip ; Silk, Tim J. ; Skokauskas, Norbert ; Carlos Soliva Vila, Juan ; Soloveva, Anastasiia ; Stevens, Michael C. ; Sudre, Gustavo ; Tamm, Leanne ; Thompson, Paul M. ; Tovar‐Moll, Fernanda ; Erp, Theo GM ; Vance, Alasdair ; Vilarroya, Oscar ; Vives‐Gilabert, Yolanda ; Walitza, Susanne ; Yoncheva, Yuliya N. ; Zanetti, Marcus V. ; Ziegler, Georg C. ; Anikin, Anatoly ; Asherson, Philip ; Baranov, Alexandr ; Chaim‐Avanicini, Tiffany ; Dale, Anders M. ; Doyle, Alysa E. ; Jernigan, Terry ; Kapilushniy, Dmitry ; Mehta, Mitul ; Namazova‐Baranova, Leyla ; Novotny, Stephanie E. ; Oberwelland Weiss, Eileen ; Schwarz, Lena
Assuntos: ADHD ; Adult ; Algorithms ; Attention Deficit Disorder with Hyperactivity - diagnostic imaging ; Attention Deficit Disorder with Hyperactivity - epidemiology ; Attention deficit hyperactivity disorder ; Basal ganglia ; Brain ; Brain - diagnostic imaging ; Case-Control Studies ; Child & adolescent psychiatry ; Clustering ; Community ; community detection ; Community Relations ; Drug Use ; Drugs ; Effect Size ; effect sizes ; Etiology ; Exploratory factor analysis ; Factor Analysis ; Factor structures ; Female ; Heterogeneity ; Humans ; Intelligence tests ; Magnetic Resonance Imaging ; Male ; Males ; Medical diagnosis ; neuroanatomic heterogeneity ; Original ; subcortical volume ; Thalamus - diagnostic imaging
É parte de: Journal of child psychology and psychiatry, 2021-09, Vol.62 (9), p.1140-1149
Notas: Members from the ENIGMA‐ADHD Working Group are presented in Appendix
These authors contributed equally to this work.
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Conflict of interest statement: See Acknowledgments for full disclosures.
These authors are joint first authors.
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Members from the ENIGMA‐ADHD Working Group are presented in Appendix 1.
Descrição: Background Attention‐deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD’s etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes. Methods Using the large ENIGMA‐ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks. Results Exploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case–control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men. Conclusions Our results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case–control differences appear more pronounced at least in some of the subgroups.
Editor: England: Blackwell Publishing Ltd
Idioma: Inglês

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Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

England: Blackwell Publishing Ltd

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