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Angiotensin-converting enzyme (ace) genetic background and nutritional environment effects on experimental diabetes

A Sterman Heimann L K Abe; M Bentivoglio; Reunião Anual da Federação de Sociedades de Biologia Experimental - FeSBE (16. 2001 Caxumbu)

Resumos Caxambu: Federação de Sociedades de Biologia Experimental, 2001

Caxambu Federação de Sociedades de Biologia Experimental 2001

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  • Título:
    Angiotensin-converting enzyme (ace) genetic background and nutritional environment effects on experimental diabetes
  • Autor: A Sterman Heimann
  • L K Abe; M Bentivoglio; Reunião Anual da Federação de Sociedades de Biologia Experimental - FeSBE (16. 2001 Caxumbu)
  • Assuntos: ANATOMIA
  • É parte de: Resumos Caxambu: Federação de Sociedades de Biologia Experimental, 2001
  • Descrição: Objetivo: To study some metabolic and cardiovascular phenotypes in diabetic genetically modified mice for the ACE gene. Métodos e Resultados: Three groups of male (C57BL/6J) mice with the following genotypes, wild (+/+), heterozygous (+/-), and insertional (+/++) for the ACE gene, were studied. Three-week-old mice were randomized into control (nondiabetic -ND) or diabetic groups (D). They were either fed with an atherogenic (AD) or a control diet (CD). At 7 weeks of age, streptozotocin (STZ-125mg/kg body weight-ip) was injected. Weekly tail-cuff blood pressure (BP), blood glucose (BG), body weight (BW), and chow consumption were measured from 7 (before diabetes) until 20 weeks of age when blood samples were collected for BG determination and the heart, aorta and kidneys were removed for hystological analysis Results: No differences were observed in BP and heart rate among all groups. D -+/++ mice had a higher mortality rate than +/+ and +/- mice. In ND+ CD animals, BG was higher in +/+ then in +/- mice. BG was higher in ND + AD mice with all genotypes. The +/- mice had the highest BG and the lowest BW among diabetics, fed with CD or AD. BW decrease was more critical in the +/- group fed with CD. In the ND mice, BW was not influenced by the diet. Diabetic animals fed with AD had a higher BG than in the group treated with CD. Conclusões: It was shown that this model is adequate for the study of diabetes pathophysiology. In this context, the extreme loss of BW in
    the diabetics fed with CD is a metabolic characteristic of diabetic patients. Interestingly, it was also shown that despite of the highest BG and BW loss, +/- animals had the lowest mortality. This indicates that beside the metabolic environment, ACE genetic background is an important factor associated with mortality
  • Editor: Caxambu Federação de Sociedades de Biologia Experimental
  • Data de criação/publicação: 2001
  • Formato: p.66.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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