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Are Epigenetic Factors Implicated in Chronic Widespread Pain?

Burri, Andrea ; Marinova, Zoya ; Robinson, Mark D ; Kühnel, Brigitte ; Waldenberger, Melanie ; Wahl, Simone ; Kunze, Sonja ; Gieger, Christian ; Livshits, Gregory ; Williams, Frances Costigan, Michael

PloS one, 2016-11, Vol.11 (11), p.e0165548-e0165548 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Are Epigenetic Factors Implicated in Chronic Widespread Pain?
Autor: Burri, Andrea ; Marinova, Zoya ; Robinson, Mark D ; Kühnel, Brigitte ; Waldenberger, Melanie ; Wahl, Simone ; Kunze, Sonja ; Gieger, Christian ; Livshits, Gregory ; Williams, Frances
Costigan, Michael
Assuntos: Aged ; Amine oxidase (flavin-containing) ; Analysis ; Bioinformatics ; Biology and life sciences ; Chronic pain ; Chronic Pain - genetics ; Collagen ; Collagen (type I) ; Deoxyribonucleic acid ; Disease susceptibility ; DNA ; DNA Methylation ; Epidemiology ; Epigenesis, Genetic ; Epigenetic inheritance ; Epigenetics ; Female ; Fibromyalgia ; Fibromyalgia - genetics ; Gene expression ; Genetic aspects ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genomes ; Genomics ; Heat shock proteins ; Hospitals ; HSP20 Heat-Shock Proteins - genetics ; Humans ; Kinases ; Lectins, C-Type - genetics ; Malate dehydrogenase ; Malate Dehydrogenase - genetics ; Male ; Medical research ; Medicine, Experimental ; Mens health ; Methylation ; Middle Aged ; Monoamine oxidase ; Musculoskeletal Pain - genetics ; Pain ; Polymorphism, Single Nucleotide ; Replication ; Studies ; Twins ; Twins, Monozygotic ; Womens health
É parte de: PloS one, 2016-11, Vol.11 (11), p.e0165548-e0165548
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceptualization: AB. Formal analysis: AB ZM BK MW MR. Funding acquisition: FW. Investigation: AB FW. Methodology: AB ZM. Project administration: AB. Supervision: FW GL. Validation: BK MW SW SK CG. Visualization: ZM. Writing – original draft: AB ZM. Writing – review & editing: AB ZM MR BK MW SW SK CG.
Competing Interests: The authors declare no conflict of interest.
Descrição: Chronic widespread musculoskeletal pain (CWP) is the cardinal symptom of fibromyalgia and affects about 12% of the general population. Familial aggregation of CWP has been repeatedly demonstrated with estimated heritabilities of around 50%, indicating a genetic susceptibility. The objective of the study was to explore genome-wide disease-differentially methylated positions (DMPs) for chronic widespread pain (CWP) in a sample of unrelated individuals and a subsample of discordant monozygotic (MZ) twins. A total of N = 281 twin individuals from the TwinsUK registry, including N = 33 MZ twins discordant for self-reported CWP, were part of the discovery sample. The replication sample included 729 men and 756 women from a subsample of the KORA S4 survey-an independent population-based cohort from Southern Germany. Epigenome-wide analysis of DNA methylation was conducted using the Illumina Infinium HumanMethylation 450 DNA BeadChip in both the discovery and replication sample. Of our 40 main loci that were carried forward for replication, three CPGs reached significant p-values in the replication sample, including malate dehydrogenase 2 (MDH2; p-value 0.017), tetranectin (CLEC3B; p-value 0.039), and heat shock protein beta-6 (HSPB6; p-value 0.016). The associations between the collagen type I, alpha 2 chain (COL1A2) and monoamine oxidase B (MAOB) observed in the discovery sample-both of which have been previously reported to be biological candidates for pain-could not be replicated. Our results may serve as a starting point to encourage further investigation in large and independent population-based cohorts of DNA methylation and other epigenetic changes as possible disease mechanisms in CWP. Ultimately, understanding the key mechanisms underlying CWP may lead to new treatments and inform clinical practice.
Editor: United States: Public Library of Science
Idioma: Inglês

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Are Epigenetic Factors Implicated in Chronic Widespread Pain?

Burri, Andrea ; Marinova, Zoya ; Robinson, Mark D ; Kühnel, Brigitte ; Waldenberger, Melanie ; Wahl, Simone ; Kunze, Sonja ; Gieger, Christian ; Livshits, Gregory ; Williams, Frances Costigan, Michael

United States: Public Library of Science

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