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Anticomplement Activity of Terpenoids from the Spores of Ganoderma lucidum

Min, Byung Sun ; Gao, Jiang Jing ; Hattori, Masao ; Lee, Hyeong Kyu ; Kim, Young Ho

Planta medica, 2001-12, Vol.67 (9), p.811-814 [Periódico revisado por pares]

Stuttgart: Thieme

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Título:
Anticomplement Activity of Terpenoids from the Spores of Ganoderma lucidum
Autor: Min, Byung Sun ; Gao, Jiang Jing ; Hattori, Masao ; Lee, Hyeong Kyu ; Kim, Young Ho
Assuntos: Biological and medical sciences ; Complement Activation - drug effects ; Complement Inactivator Proteins - chemistry ; Complement Inactivator Proteins - pharmacology ; Drugs, Chinese Herbal ; General pharmacology ; Hemolysis - drug effects ; Hemolysis - immunology ; Humans ; Lanosterol - analogs & derivatives ; Lanosterol - chemistry ; Lanosterol - isolation & purification ; Lanosterol - pharmacology ; Magnetic Resonance Spectroscopy ; Medical sciences ; Original Paper ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Reishi ; Stereoisomerism ; Triterpenes - chemistry ; Triterpenes - isolation & purification ; Triterpenes - pharmacology
É parte de: Planta medica, 2001-12, Vol.67 (9), p.811-814
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Descrição: Abstract A new lanostane-type terpenoid, lucidenic acid SP1 (1), was isolated from a CHCl 3 -soluble fraction of GANODERMA LUCIDUM spores together with four other known compounds (2 - 5). The structure of lucidenic acid SP1 was determined to be 3β,7β-dihydroxy-4,4,14α-trimethyl-11,15-dioxo-5α-chol-8-en-24-oic acid by spectroscopic means including 2D-NMR. Twelve triterpenes (1 - 12) isolated from G. LUCIDUM spores were investigated IN VITRO for their anticomplementary activity. Compounds 1 - 5 were inactive, whereas ganoderiol F (8), ganodermanondiol (9) and ganodermanontriol (10) showed a strong anticomplement activity against the classical pathway (CP) of the complement system with IC 50 values of 4.8, 41.7, and 17.2 μM, respectively. The potency of these triterpene alcohols (8 - 10) in inhibiting CP activity was improved when the number of hydroxymethyl groups on the side chain moiety is increased. On the other hand, the ganoderic acids 1 - 7, which contain a carboxyl group in the side chain, and lucidumols A and B (11, 12) had little activity on this system.
Editor: Stuttgart: Thieme
Idioma: Alemão;Inglês

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Anticomplement Activity of Terpenoids from the Spores of Ganoderma lucidum

Min, Byung Sun ; Gao, Jiang Jing ; Hattori, Masao ; Lee, Hyeong Kyu ; Kim, Young Ho

Stuttgart: Thieme

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