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Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer

Barontini, Jonathan ; Antinucci, Marco ; Tofanelli, Sergio ; Cammalleri, Maurizio ; Dal Monte, Massimo ; Gemignani, Federica ; Vodicka, Pavel ; Marangoni, Roberto ; Vodickova, Ludmila ; Kupcinskas, Juozas ; Vymetalkova, Veronika ; Forsti, Asta ; Canzian, Federico ; Stein, Angelika ; Moreno, Victor ; Mastrodonato, Nicola ; Tavano, Francesca ; Panza, Anna ; Barale, Roberto ; Landi, Stefano ; Campa, Daniele

BMC gastroenterology, 2017-09, Vol.17 (1), p.104-104, Article 104 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer
Autor: Barontini, Jonathan ; Antinucci, Marco ; Tofanelli, Sergio ; Cammalleri, Maurizio ; Dal Monte, Massimo ; Gemignani, Federica ; Vodicka, Pavel ; Marangoni, Roberto ; Vodickova, Ludmila ; Kupcinskas, Juozas ; Vymetalkova, Veronika ; Forsti, Asta ; Canzian, Federico ; Stein, Angelika ; Moreno, Victor ; Mastrodonato, Nicola ; Tavano, Francesca ; Panza, Anna ; Barale, Roberto ; Landi, Stefano ; Campa, Daniele
Assuntos: Aged ; Alcohol ; Aspirin ; Bitter taste ; Case-Control Studies ; Colon ; Colon cancer ; Colonic diseases ; Colonic Neoplasms - genetics ; Colorectal cancer ; Colorectal carcinoma ; Czech Republic ; Càncer colorectal ; Còlon ; Deoxyribonucleic acid ; Disease susceptibility ; DNA ; Female ; Gastric cancer ; Gastroenterology ; Gender ; Genes ; Genetic aspects ; Genetic Association Studies ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genetic variability ; Genomes ; Heritability ; Humans ; Hypotheses ; Italy ; Ligands ; Lithuania ; Malalties del còlon ; Male ; Medical prognosis ; Middle Aged ; Physiological aspects ; Polimorfisme genètic ; Polymorphism, Single Nucleotide ; Polymorphisms ; Receptors, G-Protein-Coupled - genetics ; Rectal cancer ; Rectal Neoplasms - genetics ; Rectum ; Risk factors ; Salicin ; Single-nucleotide polymorphism ; Spain ; Statistical analysis ; Studies ; TAS2R16 ; Taste receptors
É parte de: BMC gastroenterology, 2017-09, Vol.17 (1), p.104-104, Article 104
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Genetics plays an important role in the susceptibility to sporadic colorectal cancer (CRC). In the last 10 years genome-wide association studies (GWAS) have identified over 40 independent low penetrance polymorphic variants. However, these loci only explain around 1‑4% of CRC heritability, highlighting the dire need of identifying novel risk loci. In this study, we focused our attention on the genetic variability of the TAS2R16 gene, encoding for one of the bitter taste receptors that selectively binds to salicin, a natural antipyretic that resembles aspirin. Given the importance of inflammation in CRC, we tested whether polymorphic variants in this gene could affect the risk of developing this neoplasia hypothesizing a role of TAS2R16 in modulating chronic inflammation within the gut. We performed an association study using 6 tagging SNPs, (rs860170, rs978739, rs1357949, rs1525489, rs6466849, rs10268496) that cover all TAS2R16 genetic variability. The study was carried out on 1902 CRC cases and 1532 control individuals from four European countries. We did not find any statistically significant association between risk of developing CRC and selected SNPs. However, after stratification by histology (colon vs. rectum) we found that rs1525489 was associated with increased risk of rectal cancer with a (P of = 0.0071). Our data suggest that polymorphisms within TAS2R16 gene do not have a strong influence on colon cancer susceptibility, but a possible role in rectal cancer should be further evaluated in larger cohorts.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer

England: BioMed Central Ltd

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