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Clinical and epidemiological features of ulcerative colitis patients in Sardinia, Italy: Results from a multicenter study

Magrì, Salvatore ; Demurtas, Mauro ; Onidi, Maria Francesca ; Picchio, Marcello ; Elisei, Walter ; Marzo, Manuela ; Miculan, Federica ; Manca, Roberto ; Dore, Maria Pina ; Quarta Colosso, Bianca Maria ; Cicu, Antonio ; Cugia, Luigi ; Carta, Monica ; Binaghi, Laura ; Usai, Paolo ; Lai, Mariantonia ; Chicco, Fabio ; Fantini, Massimo Claudio ; Armuzzi, Alessandro ; Mocci, Giammarco

World journal of clinical cases, 2022-10, Vol.10 (30), p.10921-10930

Baishideng Publishing Group Inc

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  • Título:
    Clinical and epidemiological features of ulcerative colitis patients in Sardinia, Italy: Results from a multicenter study
  • Autor: Magrì, Salvatore ; Demurtas, Mauro ; Onidi, Maria Francesca ; Picchio, Marcello ; Elisei, Walter ; Marzo, Manuela ; Miculan, Federica ; Manca, Roberto ; Dore, Maria Pina ; Quarta Colosso, Bianca Maria ; Cicu, Antonio ; Cugia, Luigi ; Carta, Monica ; Binaghi, Laura ; Usai, Paolo ; Lai, Mariantonia ; Chicco, Fabio ; Fantini, Massimo Claudio ; Armuzzi, Alessandro ; Mocci, Giammarco
  • Assuntos: Observational Study
  • É parte de: World journal of clinical cases, 2022-10, Vol.10 (30), p.10921-10930
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Author contributions: Magrì S and Mocci G performed the study design, data capture, and data validation; Mgrì S, Demurtas M, and Picchio M performed the statistical analyses; Magrì S drafted the manuscript; Magrì S, Demurtas M, Onidi MF, Picchio M, Elisei W, Marzo M, Miculan F, Manca R, Dore MP, Quarta Colosso BM, Cicu A, Cugia L, Pisanu R, Carta M, Binaghi L, Usai P, Lai M, Chicco F, Fantini MC, Cabras F, Armuzzi A, and Mocci G performed the data capture and revised the manuscript; Mocci G approved the final version of the manuscript.
    Corresponding author: Salvatore Magrì, MD, Academic Research, Department of Medical Sciences and Public Health, University of Cagliari, Presidio Policlinico of Monserrato, Cagliari, SS 554 km 4500, Monserrato 09042, Italy. salvo10ms@libero.it
  • Descrição: BACKGROUNDThere are little data on the epidemiological and clinical features of adult patients with ulcerative colitis (UC) in the different Italian regions, mainly derived from the absence of a national registry. This prevents correct interpretation of the disease burden. AIMTo assess the main clinical and epidemiological features of adult patients diagnosed with UC in Sardinia, Italy. METHODSWe performed a multicenter, observational, cross-sectional study that included adult patients with UC enrolled in seven gastroenterology unit centers in Sardinia. Data were obtained from the patients' medical records and from a questionnaire administered at the inclusion visit. RESULTSFour hundred and forty-two patients with UC were included. The median age at diagnosis was 39 years (interquartile range 28-48). After a median disease duration of 10 years, 53 patients experienced proximal extension of proctitis or left-sided colitis. Seventy-five patients developed extraintestinal manifestations. Nineteen patients (4.3%) developed cancer: two with colorectal cancer and seventeen with extracolonic cancers. Mesalazine (5-ASA) remains the mainstay of treatment for UC. Overall, 95 patients (21.5%) were treated with one or more biologic agents, whereas 15 patients (3.4%) underwent surgery, mostly colectomy. CONCLUSIONOur results provide important insights into the clinical and epidemiological features of patients with UC, and while waiting for a national Italian registry, present eligible data on the UC population in Sardinia.
  • Editor: Baishideng Publishing Group Inc
  • Idioma: Inglês
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