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β-Cell deterioration during diabetes: what's in the gun?
Robertson
,
R
. Paul
Trends in endocrinology and metabolism, 2009-10, Vol.20 (8), p.388-393
[Periódico revisado por pares]
United States: Elsevier Ltd
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Título:
β-Cell deterioration during diabetes: what's in the gun?
Autor:
Robertson
,
R
. Paul
Assuntos:
Animals
;
Cytokines - metabolism
;
Diabetes Mellitus, Type 2 - metabolism
;
Diabetes Mellitus, Type 2 - pathology
;
Endocrinology & Metabolism
;
Humans
;
Insulin Resistance - physiology
;
Insulin-Secreting Cells - metabolism
;
Insulin-Secreting Cells - pathology
;
Models, Biological
;
Oxidative Stress - physiology
É parte de:
Trends in endocrinology and metabolism, 2009-10, Vol.20 (8), p.388-393
Notas:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
ObjectType-Review-1
Descrição:
Clinical management of patients with type 2 diabetes (T2D) successfully prevents extreme hyperglycemia but does not precisely control glucose levels throughout the day. The pathogenesis of T2D is akin to a double-barrel shotgun. The first trigger causes an explosion that sets genetic expression of the disease in motion; the second trigger discharges a host of environmental factors that worsen its clinical course. Candidate shells include glucolipotoxicity, cytokines, oxidative and endoplasmic reticulum stress and insulin resistance. This review considers how each candidate adversely impacts β-cell function to create the downward spiral of glycemic control. Their roles in pathogenesis raise possibilities for new drug therapies designed to protect against adverse effects of residual hyperglycemia in patients treated with conventional drugs.
Editor:
United States: Elsevier Ltd
Idioma:
Inglês
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