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Toll-like receptors 2, 3 and 4 and thymic stromal lymphopoietin expression in fatal asthma

Ferreira, D. S. ; Annoni, R. ; Silva, L. F. F. ; Buttignol, M. ; Santos, A. B. G. ; Medeiros, M. C. R. ; Andrade, L. N. S. ; Yick, C. Y. ; Sterk, P. J. ; Sampaio, J. L. M. ; Dolhnikoff, M. ; Wenzel, S. E. ; Mauad, T.

Clinical and experimental allergy, 2012-10, Vol.42 (10), p.1459-1471 [Periódico revisado por pares]

Oxford: Blackwell Publishing Ltd

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Título:
Toll-like receptors 2, 3 and 4 and thymic stromal lymphopoietin expression in fatal asthma
Autor: Ferreira, D. S. ; Annoni, R. ; Silva, L. F. F. ; Buttignol, M. ; Santos, A. B. G. ; Medeiros, M. C. R. ; Andrade, L. N. S. ; Yick, C. Y. ; Sterk, P. J. ; Sampaio, J. L. M. ; Dolhnikoff, M. ; Wenzel, S. E. ; Mauad, T.
Assuntos: Adult ; Asthma ; Asthma - immunology ; Asthma - mortality ; Biological and medical sciences ; Chronic obstructive pulmonary disease, asthma ; Cytokines - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; immunohistochemistry ; Inflammation - immunology ; innate immunity ; lung ; Lung - immunology ; Male ; Medical research ; Medical sciences ; Middle Aged ; Pneumology ; Thymic Stromal Lymphopoietin ; Toll-Like Receptor 2 - metabolism ; Toll-Like Receptor 3 - metabolism ; Toll-Like Receptor 4 - metabolism ; Up-Regulation
É parte de: Clinical and experimental allergy, 2012-10, Vol.42 (10), p.1459-1471
Notas: Table S1. Toll-like receptors 2 (TLR2), 3 (TLR3) and 4 (TLR4) expression in endobronchial biopsies from mild asthmatics (MA) and healthy controls (HCtrl)
Conselho Nacional de Desenvolvimento Científico e Tecnológico
ArticleID:CEA4047
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ark:/67375/WNG-27X6C1K3-G
United States National Institutes of Health - No. RO1 AI0677080
istex:69D44F76F2F21B4F6FE7165434FC0C40C3EA9247
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Summary Background Airway inflammation in asthma involves innate immune responses. Toll‐like receptors (TLRs) and thymic stromal lymphopoietin (TSLP) are thought to be involved in airway inflammation, but their expression in asthmatics’ both large and small airways has not been investigated. Objective To analyse the expression of TLR2, TLR3, TLR4 and TSLP in large and small airways of asthmatics and compare their expression in smoking and non‐smoking asthmatics; to investigate whether TLR expression is associated with eosinophilic or neutrophilic airway inflammation and with Mycoplasma pneumoniae and Chlamydophila pneumoniae infection. Methods Using immunohistochemistry and image analysis, we investigated TLR2, TLR3, TLR4 and TSLP expression in large and small airways of 24 victims of fatal asthma, FA, (13 non‐smokers, 11 smokers) and nine deceased control subjects (DCtrl). TLRs were also measured in 18 mild asthmatics (MA) and 12 healthy controls (HCtrl). M. pneumoniae and C. pneumoniae in autopsy lung tissue were analysed using real‐time polymerase chain reaction. Airway eosinophils and neutrophils were measured in all subjects. Results Fatal asthma patients had higher TLR2 in the epithelial and outer layers of large and small airways compared with DCtrls. Smoking asthmatics had lower TLR2 levels in the inner and outer layers of the small airways than non‐smoking asthmatics. TSLP was increased in the epithelial and outer layers of the large airways of FA. FA patients had greater TLR3 expression in the outer layer of large airways and greater TLR4 expression in the outer layer of small airways. Eosinophilic airway inflammation was associated with TLR expression in the epithelium of FA. No bacterial DNA was detected in FA or DCtrls. MA and HCtrls had only a small difference in TLR3 expression. Conclusions and Clinical Relevance Increased expression of TLR 2, 3 and 4 and TSLP in fatal asthma may contribute to the acute inflammation surrounding asthma deaths.
Editor: Oxford: Blackwell Publishing Ltd
Idioma: Inglês

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Toll-like receptors 2, 3 and 4 and thymic stromal lymphopoietin expression in fatal asthma

Ferreira, D. S. ; Annoni, R. ; Silva, L. F. F. ; Buttignol, M. ; Santos, A. B. G. ; Medeiros, M. C. R. ; Andrade, L. N. S. ; Yick, C. Y. ; Sterk, P. J. ; Sampaio, J. L. M. ; Dolhnikoff, M. ; Wenzel, S. E. ; Mauad, T.

Oxford: Blackwell Publishing Ltd

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