Idioma:

Surface ligand controls silver ion release of nanosilver and its antibacterial activity against Escherichia coli

Long, Yan-Min ; Hu, Li-Gang ; Yan, Xue-Ting ; Zhao, Xing-Chen ; Zhou, Qun-Fang ; Cai, Yong ; Jiang, Gui-Bin

International journal of nanomedicine, 2017-01, Vol.12, p.3193-3206 [Periódico revisado por pares]

New Zealand: Dove Medical Press Limited

Texto completo disponível

Citações Citado por

Enviar para

Título:
Surface ligand controls silver ion release of nanosilver and its antibacterial activity against Escherichia coli
Autor: Long, Yan-Min ; Hu, Li-Gang ; Yan, Xue-Ting ; Zhao, Xing-Chen ; Zhou, Qun-Fang ; Cai, Yong ; Jiang, Gui-Bin
Assuntos: 3-Mercaptopropionic Acid - chemistry ; Alkanesulfonic Acids - chemistry ; Animals ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacokinetics ; Anti-Bacterial Agents - pharmacology ; Bacteria ; Caproates - chemistry ; Cell Membrane - drug effects ; Cell Membrane - metabolism ; Citric Acid - chemistry ; Comparative analysis ; DNA methylation ; E coli ; Escherichia coli ; Escherichia coli - drug effects ; Gram-positive bacteria ; Ligands ; Metal Nanoparticles - chemistry ; Nanomaterials ; Nanoparticles ; Nanotechnology ; Original Research ; Oxidative stress ; Particle size ; Physiological aspects ; Properties ; Reactive Oxygen Species - metabolism ; respiratory chain ; RNA polymerase ; Silver ; Silver - chemistry ; Silver - pharmacokinetics ; Silver - pharmacology ; silver ion release ; silver nanoparticle ; Sulfhydryl Compounds - chemistry ; surface chemistry ; Surface Properties ; trojan horse mechanism
É parte de: International journal of nanomedicine, 2017-01, Vol.12, p.3193-3206
Descrição: Understanding the mechanism of nanosilver-dependent antibacterial activity against microorganisms helps optimize the design and usage of the related nanomaterials. In this study, we prepared four kinds of 10 nm-sized silver nanoparticles (AgNPs) with dictated surface chemistry by capping different ligands, including citrate, mercaptopropionic acid, mercaptohexanoic acid, and mercaptopropionic sulfonic acid. Their surface-dependent chemistry and antibacterial activities were investigated. Owing to the weak bond to surface Ag, short carbon chain, and low silver ion attraction, citrate-coated AgNPs caused the highest silver ion release and the strongest antibacterial activity against , when compared to the other tested AgNPs. The study on the underlying antibacterial mechanisms indicated that cellular membrane uptake of Ag, NAD /NADH ratio increase, and intracellular reactive oxygen species (ROS) generation were significantly induced in both AgNP and silver ion exposure groups. The released silver ions from AgNPs inside cells through a Trojan-horse-type mechanism were suggested to interact with respiratory chain proteins on the membrane, interrupt intracellular O reduction, and induce ROS production. The further oxidative damages of lipid peroxidation and membrane breakdown caused the lethal effect on . Altogether, this study demonstrated that AgNPs exerted antibacterial activity through the release of silver ions and the subsequent induction of intracellular ROS generation by interacting with the cell membrane. The findings are helpful in guiding the controllable synthesis through the regulation of surface coating for medical care purpose.
Editor: New Zealand: Dove Medical Press Limited
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 9 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Surface ligand controls silver ion release of nanosilver and its antibacterial activity against Escherichia coli

Long, Yan-Min ; Hu, Li-Gang ; Yan, Xue-Ting ; Zhao, Xing-Chen ; Zhou, Qun-Fang ; Cai, Yong ; Jiang, Gui-Bin

New Zealand: Dove Medical Press Limited

Buscando em bases de dados remotas. Favor aguardar.