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Behavior and brain enzymatic changes after long-term intoxication with cadmium salt or contaminated potatoes

Gonçalves, Jamile F. ; Nicoloso, Fernando T. ; da Costa, Pauline ; Farias, Júlia G. ; Carvalho, Fabiano B. ; da Rosa, Michelle M. ; Gutierres, Jessié M. ; Abdalla, Fátima H. ; Pereira, Juliana S.F. ; Dias, Glaecir R.M. ; Barbosa, Nilda B.V. ; Dressler, Valderi L. ; Rubin, Maribel A. ; Morsch, Vera M. ; Schetinger, Maria Rosa C.

Food and chemical toxicology, 2012-10, Vol.50 (10), p.3709-3718 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Título:
Behavior and brain enzymatic changes after long-term intoxication with cadmium salt or contaminated potatoes
Autor: Gonçalves, Jamile F. ; Nicoloso, Fernando T. ; da Costa, Pauline ; Farias, Júlia G. ; Carvalho, Fabiano B. ; da Rosa, Michelle M. ; Gutierres, Jessié M. ; Abdalla, Fátima H. ; Pereira, Juliana S.F. ; Dias, Glaecir R.M. ; Barbosa, Nilda B.V. ; Dressler, Valderi L. ; Rubin, Maribel A. ; Morsch, Vera M. ; Schetinger, Maria Rosa C.
Assuntos: Acetylcholinesterase - metabolism ; AChE ; Animals ; Anxiety ; Behavior, Animal - drug effects ; Biological and medical sciences ; Brain - enzymology ; cadmium ; Cadmium - toxicity ; cerebellum ; Chemical and industrial products toxicology. Toxic occupational diseases ; chronic exposure ; cognition ; cortex ; Diet ; Food Contamination - analysis ; hypothalamus ; Male ; Maze Learning - drug effects ; Medical sciences ; Memory ; Metals and various inorganic compounds ; micropropagation ; Na+,K+-ATPase ; planting ; plantlets ; poisoning ; potatoes ; Random Allocation ; Rats ; sand ; Sodium-Potassium-Exchanging ATPase - genetics ; Sodium-Potassium-Exchanging ATPase - metabolism ; Solanum tuberosum ; Solanum tuberosum - chemistry ; Toxicology ; trays ; tubers
É parte de: Food and chemical toxicology, 2012-10, Vol.50 (10), p.3709-3718
Notas: http://dx.doi.org/10.1016/j.fct.2012.07.016
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Descrição: ► Long-term exposure to Cd salt (1, 5 and 25mg/kg) as well as Cd accumulated in potato tubers caused impairment of memory. ► Rats fed potato diet per se showed a lower anxiety-like behavior. ► Rats fed 25mg/kg Cd diet showed a higher anxiety-like behavior. ► Cd intoxication increases the AChE activities in cerebral structures of rats. ► Cd exposure decreases Na+,K+-ATPase activity in cerebral structures of rats. This study investigated the cadmium (Cd) intoxication on cognitive, motor and anxiety performance of rats subjected to long-term exposure to diet with Cd salt or with Cd from contaminated potato tubers. Potato plantlets were micropropagated in MS medium and transplanted to plastic trays containing sand. Tubers were collected, planted in sand boxes and cultivated with 0 or 10μM Cd and, after were oven-dried, powder processed and used for diet. Rats were divided into six groups and fed different diets for 5months: control, potato, potato+Cd, 1, 5 or 25mg/kg CdCl2. Cd exposure increased Cd concentration in brain regions. There was a significant decrease in the step-down latency in Cd-intoxicated rats and, elevated plus maze task revealed an anxiolytic effect in rats fed potato diet per se, and an anxiogenic effect in rats fed 25mg/kg Cd. The brain structures of rats exposed to Cd salt or Cd from tubers showed an increased AChE activity, but Na+,K+-ATPase decreased in cortex, hypothalamus, and cerebellum. Therefore, we suggest an association between the long-term diet of potato tuber and a clear anxiolytic effect. Moreover, we observed an impaired cognition and enhanced anxiety-like behavior displayed by Cd-intoxicated rats coupled with a marked increase of brain Cd concentration, and increase and decrease of AChE and Na+,K+-ATPase activities, respectively.
Editor: Oxford: Elsevier Ltd
Idioma: Inglês

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Behavior and brain enzymatic changes after long-term intoxication with cadmium salt or contaminated potatoes

Oxford: Elsevier Ltd

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