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Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation?

Abreu, Marcus da Matta ; Almeida, Francine Maria de ; Santos, Kelli Borges Dos ; Assis, Emílio Augusto Campos Pereira de ; Hamada, Rafael Kenji Fonseca ; Jatene, Fabio Biscegli ; Pêgo-Fernandes, Paulo Manuel ; Pazetti, Rogerio

Jornal brasileiro de pneumologia, 2018-09, Vol.44 (5), p.378-382 [Periódico revisado por pares]

Brazil: Sociedade Brasileira de Pneumologia e Tisiologia

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Título:
Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation?
Autor: Abreu, Marcus da Matta ; Almeida, Francine Maria de ; Santos, Kelli Borges Dos ; Assis, Emílio Augusto Campos Pereira de ; Hamada, Rafael Kenji Fonseca ; Jatene, Fabio Biscegli ; Pêgo-Fernandes, Paulo Manuel ; Pazetti, Rogerio
Assuntos: Animals ; Apoptose ; Apoptosis ; Artigo Original ; Azul de metileno ; Female ; Immunohistochemistry ; Inflamação ; Inflammation - prevention & control ; Lung Transplantation - methods ; Methylene Blue - therapeutic use ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury - prevention & control ; RESPIRATORY SYSTEM ; Transplante de pulmão ; Traumatismo por reperfusão
É parte de: Jornal brasileiro de pneumologia, 2018-09, Vol.44 (5), p.378-382
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: To evaluate whether methylene blue (MB) could minimize the effects of ischemia-reperfusion injury in the nonischemic lung on a lung transplantation rodent model. Forty female Sprague-Dawley rats were divided into 20 donors and 20 recipients. The 20 recipient rats were divided into two groups (n = 10) according to the treatment (0.9% saline vs. 1% MB solutions). All animals underwent unilateral lung transplantation. Recipients received 2 mL of saline or MB intraperitoneally prior to transplantation. After 2 h of reperfusion, the animals were euthanized and histopathological and immunohistochemical analyses were performed in the nonischemic lung. There was a significant decrease in inflammation-neutrophil count and intercellular adhesion molecule-1 (ICAM-1) expression in lung parenchyma were higher in the saline group in comparison with the MB group-and in apoptosis-caspase-3 expression was higher in the saline group and Bcl-2 expression was higher in MB group. MB is an effective drug for the protection of nonischemic lungs against inflammation and apoptosis following unilateral lung transplantation in rats.
Editor: Brazil: Sociedade Brasileira de Pneumologia e Tisiologia
Idioma: Inglês;Português

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Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation?

Abreu, Marcus da Matta ; Almeida, Francine Maria de ; Santos, Kelli Borges Dos ; Assis, Emílio Augusto Campos Pereira de ; Hamada, Rafael Kenji Fonseca ; Jatene, Fabio Biscegli ; Pêgo-Fernandes, Paulo Manuel ; Pazetti, Rogerio

Brazil: Sociedade Brasileira de Pneumologia e Tisiologia

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