skip to main content
Idioma:

Structure of African Swine Fever Virus and Associated Molecular Mechanisms Underlying Infection and Immunosuppression: A Review

Wang, Yue ; Kang, Weifang ; Yang, Wenping ; Zhang, Jing ; Li, Dan ; Zheng, Haixue

Frontiers in immunology, 2021-09, Vol.12, p.715582-715582 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

Texto completo disponível

Citações Citado por
  • Título:
    Structure of African Swine Fever Virus and Associated Molecular Mechanisms Underlying Infection and Immunosuppression: A Review
  • Autor: Wang, Yue ; Kang, Weifang ; Yang, Wenping ; Zhang, Jing ; Li, Dan ; Zheng, Haixue
  • Assuntos: African Swine Fever - immunology ; African Swine Fever - metabolism ; African Swine Fever - virology ; African swine fever virus ; African Swine Fever Virus - physiology ; animal disease ; Animals ; Apoptosis ; Biomarkers ; Disease Susceptibility ; Gene Expression Regulation, Viral ; Genome, Viral ; Genomics - methods ; Host-Pathogen Interactions - immunology ; Immunocompromised Host ; Immunology ; Immunomodulation ; immunosuppression ; infection ; nucleocytoplasmic large DNA virus ; Open Reading Frames ; Swine ; Virus Replication
  • É parte de: Frontiers in immunology, 2021-09, Vol.12, p.715582-715582
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    This article was submitted to Viral Immunology, a section of the journal Frontiers in Immunology
    Edited by: Paul Roesch, University of Bayreuth, Germany
    Reviewed by: Margarida Simões, University of Evora, Portugal; Fernando Costa Ferreira, University of Lisbon, Portugal
  • Descrição: African swine fever (ASF) is an acute, highly contagious, and deadly infectious disease. The mortality rate of the most acute and acute ASF infection is almost 100%. The World Organization for Animal Health [Office International des épizooties (OIE)] lists it as a legally reported animal disease and China lists it as class I animal epidemic. Since the first diagnosed ASF case in China on August 3, 2018, it has caused huge economic losses to animal husbandry. ASF is caused by the African swine fever virus (ASFV), which is the only member of Asfarviridae family. ASFV is and the only insect-borne DNA virus belonging to the Nucleocytoplasmic Large DNA Viruses (NCLDV) family with an icosahedral structure and an envelope. Till date, there are still no effective vaccines or antiviral drugs for the prevention or treatment of ASF. The complex viral genome and its sophisticated ability to regulate the host immune response may be the reason for the difficulty in developing an effective vaccine. This review summarizes the recent findings on ASFV structure, the molecular mechanism of ASFV infection and immunosuppression, and ASFV-encoded proteins to provide comprehensive proteomic information for basic research on ASFV. In addition, it also analyzes the results of previous studies and speculations on the molecular mechanism of ASFV infection, which aids the study of the mechanism of clinical pathological phenomena, and provides a possible direction for an intensive study of ASFV infection mechanism. By summarizing the findings on molecular mechanism of ASFV- regulated host cell immune response, this review provides orientations and ideas for fundamental research on ASFV and provides a theoretical basis for the development of protective vaccines against ASFV.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.