skip to main content
Visitante
Meu Espaço
Minha Conta
Sair
Identificação
This feature requires javascript
Tags
Revistas Eletrônicas (eJournals)
Livros Eletrônicos (eBooks)
Bases de Dados
Bibliotecas USP
Ajuda
Ajuda
Idioma:
Inglês
Espanhol
Português
This feature required javascript
This feature requires javascript
Primo Search
Busca Geral
Busca Geral
Acervo Físico
Acervo Físico
Produção Intelectual da USP
Produção USP
Search For:
Clear Search Box
Search in:
Busca Geral
Or select another collection:
Search in:
Busca Geral
Busca Avançada
Busca por Índices
This feature requires javascript
This feature requires javascript
Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution
Glenfield, Cian ; Innan, Hideki
Genes, 2021-08, Vol.12 (9), p.1376
[Periódico revisado por pares]
Switzerland: MDPI AG
Texto completo disponível
Citações
Citado por
Exibir Online
Detalhes
Resenhas & Tags
Mais Opções
Nº de Citações
This feature requires javascript
Enviar para
Adicionar ao Meu Espaço
Remover do Meu Espaço
E-mail (máximo 30 registros por vez)
Imprimir
Link permanente
Referência
EasyBib
EndNote
RefWorks
del.icio.us
Exportar RIS
Exportar BibTeX
This feature requires javascript
Título:
Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution
Autor:
Glenfield, Cian
;
Innan, Hideki
Assuntos:
Cancer
;
cancer genome
;
Carcinogenesis - genetics
;
Cell cycle
;
Cell division
;
Cell growth
;
Chromosome rearrangements
;
Chromosomes
;
Cloning
;
Dihydrofolate reductase
;
Evolution
;
Evolution, Molecular
;
Evolutionary genetics
;
Gene amplification
;
Gene Duplication
;
Gene expression
;
Gene Fusion
;
Gene rearrangement
;
genome rearrangement
;
Genomes
;
Genomic instability
;
Genomics
;
Humans
;
Mutation
;
Neoplasms - genetics
;
Review
;
Tumorigenesis
;
Tumors
;
tumour evolution
É parte de:
Genes, 2021-08, Vol.12 (9), p.1376
Descrição:
Chromosomal rearrangement and genome instability are common features of cancer cells in human. Consequently, gene duplication and gene fusion events are frequently observed in human malignancies and many of the products of these events are pathogenic, representing significant drivers of tumourigenesis and cancer evolution. In certain subsets of cancers duplicated and fused genes appear to be essential for initiation of tumour formation, and some even have the capability of transforming normal cells, highlighting the importance of understanding the events that result in their formation. The mechanisms that drive gene duplication and fusion are unregulated in cancer and they facilitate rapid evolution by selective forces akin to Darwinian survival of the fittest on a cellular level. In this review, we examine current knowledge of the landscape and prevalence of gene duplication and gene fusion in human cancers.
Editor:
Switzerland: MDPI AG
Idioma:
Inglês
Links
View this record in MEDLINE/PubMed
This feature requires javascript
This feature requires javascript
Voltar para lista de resultados
Anterior
Resultado
6
Avançar
This feature requires javascript
This feature requires javascript
Buscando em bases de dados remotas. Favor aguardar.
Buscando por
em
scope:(USP_PRODUCAO),scope:(USP_EBOOKS),scope:("PRIMO"),scope:(USP),scope:(USP_EREVISTAS),scope:(USP_FISICO),primo_central_multiple_fe
Mostrar o que foi encontrado até o momento
This feature requires javascript
This feature requires javascript