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Multiple infection with resistant and sensitive M. tuberculosis strains during treatment of pulmonary tuberculosis patients

Baldeviano-Vidalón ; Quispe-Torres ; Bonilla-Asalde ; Gastiaburú-Rodriguez ; Pro-Cuba ; Llanos-Zavalaga

The international journal of tuberculosis and lung disease, 2005-10, Vol.9 (10), p.1155-1160 [Periódico revisado por pares]

Paris, France: IUATLD

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Título:
Multiple infection with resistant and sensitive M. tuberculosis strains during treatment of pulmonary tuberculosis patients
Autor: Baldeviano-Vidalón ; Quispe-Torres ; Bonilla-Asalde ; Gastiaburú-Rodriguez ; Pro-Cuba ; Llanos-Zavalaga
Assuntos: Adolescent ; Adult ; Antitubercular Agents - administration & dosage ; Bacterial diseases ; Biological and medical sciences ; Cross-Sectional Studies ; DNA Fingerprinting ; DNA, Bacterial - genetics ; Drug Resistance - genetics ; Female ; Human bacterial diseases ; Humans ; Incidence ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Multiple Infections ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - genetics ; Peru ; Peru - epidemiology ; Pneumology ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Respiratory system : syndromes and miscellaneous diseases ; RFLP ; Tuberculosis ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Multidrug-Resistant - drug therapy ; Tuberculosis, Multidrug-Resistant - epidemiology ; Tuberculosis, Multidrug-Resistant - microbiology ; Tuberculosis, Pulmonary - drug therapy ; Tuberculosis, Pulmonary - epidemiology ; Tuberculosis, Pulmonary - microbiology
É parte de: The international journal of tuberculosis and lung disease, 2005-10, Vol.9 (10), p.1155-1160
Notas: 1027-3719(20051001)9:10L.1155;1-
(R) Medicine - General
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: OBJECTIVE: To identify multiple infection events during anti-tuberculosis treatment in a cohort of pulmonary tuberculosis (PTB) patients in a local hospital in Callao, Peru.DESIGN: We evaluated 10 patients with smear-positive PTB who had two or more different isolates available during DOTS treatment. We determined drug susceptibility to rifampicin, isoniazid, ethambutol and streptomycin, and performed molecular sub-typing by restriction fragment length polymorphism (RFLP) and PCR.RESULTS: Drug susceptibility patterns changed from sensitive to resistant in the first and subsequent isolate of three of 10 patients. This change coincided with a dramatic alteration of their DNA fingerprint profile. We ruled out the possibility of cross-contamination or potential labelling errors.CONCLUSION: We found multiple infections with sensitive and resistant strains of Mycobacterium tuberculosis throughout the same treatment scheme in three patients with PTB. Further studies are needed to determine the frequency of exogenous re-infection and simultaneous/mixed infection and their impact on TB control in Peru.
Editor: Paris, France: IUATLD
Idioma: Inglês

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Multiple infection with resistant and sensitive M. tuberculosis strains during treatment of pulmonary tuberculosis patients

Baldeviano-Vidalón ; Quispe-Torres ; Bonilla-Asalde ; Gastiaburú-Rodriguez ; Pro-Cuba ; Llanos-Zavalaga

Paris, France: IUATLD

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