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Comparability of 11 different equations for estimating LDL cholesterol on different analysers

Rossouw, Helgard M. ; Nagel, Susanna E. ; Pillay, Tahir S.

Clinical chemistry and laboratory medicine, 2021-11, Vol.59 (12), p.1930-1943 [Periódico revisado por pares]

Germany: De Gruyter

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  • Título:
    Comparability of 11 different equations for estimating LDL cholesterol on different analysers
  • Autor: Rossouw, Helgard M. ; Nagel, Susanna E. ; Pillay, Tahir S.
  • Assuntos: Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - blood ; Atherosclerosis - diagnosis ; Atherosclerosis - therapy ; Bias ; Cardiovascular diseases ; Cholesterol ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Density ; equation ; Estimation ; Friedewald ; High density lipoprotein ; Humans ; Lipids ; Low density lipoprotein ; Martin/Hopkins ; Mathematical analysis ; Median (statistics) ; Patients ; Performance prediction ; Reagents ; Statins ; Triglycerides ; Triglycerides - blood
  • É parte de: Clinical chemistry and laboratory medicine, 2021-11, Vol.59 (12), p.1930-1943
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    content type line 23
  • Descrição: Low-density lipoprotein cholesterol (LDL-C) estimation is critical for risk classification, prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). Predictive equations and direct LDL-C are used. We investigated the comparability between the Martin/Hopkins, Sampson, Friedewald and eight other predictive equations on two analysers, to determine whether the equation or analyser influences predicted LDL-C result. In two unpaired datasets, 9,995 lipid profiles were analysed by the Abbott Architect and 4,782 by the Roche Cobas analysers. Non-parametric statistics and Bland Altman plots were used to compare LDL-C. On the Abbott analyser; the Martin/Hopkins, Sampson and Friedewald LDL-C were comparable (median bias ≤1.8%) over a range of 1-4.9 mmol/L. On the Roche platform, Martin/Hopkins LDL-C was comparable to Friedewald (median bias 0.3%) but not to Sampson LDL-C (median bias 25%). In patients with LDL-C <1.8 mmol/L and triglycerides (TG) ≤1.7 mmol/L, predicted LDL-C using Abbott reagents was similar between Martin/Hopkins, Sampson and Friedewald equations but not comparable using Roche reagents. Abbott reagents classified 10-20% of patients in the 1.0-1.8 mmol/L range (Martin/Hopkins 13.4%; Sampson 14.5%; Friedewald 16%; direct LDL-C 13.2%). Roche reagents classified 11-30% in the 1.0-1.8 mmol/L range (Martin/Hopkins 23%; Sampson 11%; Friedewald 25%; direct LDL-C 17%). Performance of predictive equations is influenced by the choice of analyser for total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and TG. Replacement of the Friedewald equation with Martin/Hopkins estimation to improve quality of LDL-C results can be safely implemented across analysers, whereas caution is advised regarding the Sampson equation.
  • Editor: Germany: De Gruyter
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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