Idioma:

Biomedical advances from tissue culture

Okamoto, Tetsuji ; Sato, J. Denry ; Barnes, David W. ; Sato, Gordon H.

Cytotechnology (Dordrecht), 2013-12, Vol.65 (6), p.967-971 [Periódico revisado por pares]

Dordrecht: Springer Netherlands

Texto completo disponível

Citações Citado por

Enviar para

Título:
Biomedical advances from tissue culture
Autor: Okamoto, Tetsuji ; Sato, J. Denry ; Barnes, David W. ; Sato, Gordon H.
Assuntos: Biochemistry ; Biomedicine ; Biotechnology ; Cell culture ; Cell differentiation ; Chemistry ; Chemistry and Materials Science ; Culture media ; Enrichment media ; Fibroblasts ; Growth factors ; Growth hormones ; Hypotheses ; Immunotherapy ; Intracellular signalling ; JAACT Special Issue ; Liver ; Monoclonal antibodies ; Ovaries ; Physiology ; Pluripotency ; Stem cell transplantation ; Stem cells ; Targeted cancer therapy ; Tissue culture ; Tumor cells
É parte de: Cytotechnology (Dordrecht), 2013-12, Vol.65 (6), p.967-971
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The demonstration that the “dedifferentiation” of cells commonly observed in the early days of tissue culture was due to selective overgrowth of fibroblasts led to enrichment culture techniques (alternate animal and culture passage) designed to give a selective advantage to functionally differentiated tumor cells. These experiments resulted in the derivation of a large number of functionally differentiated clonal strains of a range of cell types. These results gave rise to the hypothesis that cells in culture accurately represent cells in vivo but without the complex in vivo environment. This concept has been strengthened with the development of hormonally defined culture media in combination with functionally differentiated clonal cell lines, which have augmented the potential of tissue culture studies. The use of hormonally defined media in place of serum-supplemented media demonstrates that hormonal responses and dependencies can be discovered in culture. Discoveries of hormonal dependencies of cancer cells has led to therapies targeting intracellular signaling pathways while discoveries of hormonal responses of pluripotent cells are helping to identify the potential application of stem cells. In these and other ways tissue culture technology will continue to contribute to solving problems of human health.
Editor: Dordrecht: Springer Netherlands
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Biomedical advances from tissue culture

Okamoto, Tetsuji ; Sato, J. Denry ; Barnes, David W. ; Sato, Gordon H.

Dordrecht: Springer Netherlands

Buscando em bases de dados remotas. Favor aguardar.