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Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis

Kumar, Ayush ; Bhatia, Madhav

International journal of molecular sciences, 2021-11, Vol.22 (22), p.12136 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis
Autor: Kumar, Ayush ; Bhatia, Madhav
Assuntos: Cell adhesion ; Cell adhesion & migration ; Cell adhesion molecules ; Cell Adhesion Molecules - genetics ; Disease ; Endothelial cells ; Endothelial Cells - metabolism ; Endothelial Cells - pathology ; Enzymes ; Gastrointestinal diseases ; Humans ; Hyaluronan ; Hydrogen ; Hydrogen sulfide ; Hydrogen Sulfide - metabolism ; ICAM-1 ; Immunoglobulins ; Inflammation ; Inflammation - genetics ; Inflammation - pathology ; Inflammatory diseases ; Inflammatory response ; Integrins ; Integrins - genetics ; Leukocytes ; Leukocytes - metabolism ; Leukocytes - pathology ; MAdCAM-1 ; Multiple organ dysfunction syndrome ; Pancreas ; Pancreatitis ; Pancreatitis - genetics ; Pancreatitis - metabolism ; Pancreatitis - pathology ; Physiology ; Proteins ; Review ; Selectins ; Selectins - genetics ; Substance P ; Substance P - genetics ; Substance P - metabolism ; Sulfur ; VAP-1 ; VCAM-1
É parte de: International journal of molecular sciences, 2021-11, Vol.22 (22), p.12136
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Inflammation is a natural response to tissue injury. Uncontrolled inflammatory response leads to inflammatory disease. Acute pancreatitis is one of the main reasons for hospitalization amongst gastrointestinal disorders worldwide. It has been demonstrated that endogenous hydrogen sulfide (H S), a gasotransmitter and substance P, a neuropeptide, are involved in the inflammatory process in acute pancreatitis. Cell adhesion molecules (CAM) are key players in inflammatory disease. Immunoglobulin (Ig) gene superfamily, selectins, and integrins are involved at different steps of leukocyte migration from blood to the site of injury. When the endothelial cells get activated, the CAMs are upregulated which leads to them interacting with leukocytes. This review summarizes our current understanding of the roles H S, substance P and adhesion molecules play in acute pancreatitis.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis

Kumar, Ayush ; Bhatia, Madhav

Switzerland: MDPI AG

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