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The effect of Abelmoschus esculentus L. (Okra) extract supplementation on glycaemic control, inflammation, kidney function and expression of PPAR-α, PPAR-γ, TGF-β and Nrf-2 genes in patients with diabetic nephropathy: a triple-blind, randomised, placebo-controlled trial

Nikpayam, Omid ; Saghafi-Asl, Maryam ; Safaei, Ehsan ; Bahreyni, Nazgol ; Sadra, Vahideh ; Asgharian, Parina

British journal of nutrition, 2024-02, Vol.131 (4), p.648-657 [Periódico revisado por pares]

Cambridge, UK: Cambridge University Press

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Título:
The effect of Abelmoschus esculentus L. (Okra) extract supplementation on glycaemic control, inflammation, kidney function and expression of PPAR-α, PPAR-γ, TGF-β and Nrf-2 genes in patients with diabetic nephropathy: a triple-blind, randomised, placebo-controlled trial
Autor: Nikpayam, Omid ; Saghafi-Asl, Maryam ; Safaei, Ehsan ; Bahreyni, Nazgol ; Sadra, Vahideh ; Asgharian, Parina
Assuntos: Abelmoschus - metabolism ; Abelmoschus esculentus ; Antidiabetics ; Antioxidants ; C-reactive protein ; Cellulose ; Clinical trials ; Creatinine ; Cytokines ; Diabetes ; Diabetes Mellitus ; Diabetic Nephropathies - drug therapy ; Diabetic Nephropathies - metabolism ; Diabetic nephropathy ; Dietary Supplements ; Double-Blind Method ; Energy consumption ; GA-binding protein ; Gene expression ; Glucose ; Glycemic Control ; Growth factors ; Humans ; Hyperglycemia ; Inflammation ; Insulin ; Insulin resistance ; Kidney - metabolism ; Kidneys ; Kinases ; Nephropathy ; Nutritional Endocrinology ; Okra ; Oxidative stress ; Pathophysiology ; Patients ; Peroxisome proliferator-activated receptors ; Placebos ; Plant extracts ; PPAR alpha - genetics ; PPAR alpha - metabolism ; PPAR gamma - genetics ; PPAR gamma - metabolism ; Proteins ; Statistical analysis ; Transforming Growth Factor beta - metabolism ; Transforming growth factor-b ; Urine
É parte de: British journal of nutrition, 2024-02, Vol.131 (4), p.648-657
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Descrição: The present study was carried out to evaluate the effects of okra extract supplementation on kidney function, glycaemic control, inflammation and gene expression in patients with diabetic nephropathy (DN). A total of sixty-four DN patients based on the inclusion and exclusion criteria were recruited in this triple-blind placebo-controlled randomised clinical trial. Participants were randomly allocated to receive a 125-mg capsule of dried okra extract (DOE) (n 32) or placebo (n 32) for 10 weeks. At the baseline and endpoint of the trial, kidney function, glycaemic indices, inflammation and gene expression were evaluated. Statistical analysis showed that fasting blood glucose, HbA1c and insulin resistance significantly reduced in the DOE group although between-group analysis did not show any significant difference. Also, no significant difference was observed in urine protein, urine creatinine and high-sensitivity C-reactive protein between the two groups. Furthermore, gene expression of PPAR-α, PPAR-γ, transforming growth factor-beta and Nrf-2 did not affect the end of the trial in comparison with the baseline. According to the present study, DOE did not have impressive effects on kidney function, inflammation, glycaemic management and gene expression in patients with DN.
Editor: Cambridge, UK: Cambridge University Press
Idioma: Inglês

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The effect of Abelmoschus esculentus L. (Okra) extract supplementation on glycaemic control, inflammation, kidney function and expression of PPAR-α, PPAR-γ, TGF-β and Nrf-2 genes in patients with diabetic nephropathy: a triple-blind, randomised, placebo-controlled trial

Nikpayam, Omid ; Saghafi-Asl, Maryam ; Safaei, Ehsan ; Bahreyni, Nazgol ; Sadra, Vahideh ; Asgharian, Parina

Cambridge, UK: Cambridge University Press

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