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Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance

Dantas, Tiago J. ; Daly, Owen M. ; Morrison, Ciaran G.

Cellular and molecular life sciences : CMLS, 2012-09, Vol.69 (18), p.2979-2997 [Revista revisada por pares]

Basel: SP Birkhäuser Verlag Basel

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Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance
Autor: Dantas, Tiago J. ; Daly, Owen M. ; Morrison, Ciaran G.
Materias: Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Calcium-Binding Proteins - chemistry ; Calcium-Binding Proteins - physiology ; Cell Biology ; Cell Cycle Proteins - chemistry ; Cell Cycle Proteins - physiology ; Cellular biology ; Centrioles - metabolism ; Centrosome - metabolism ; Chromosomal Proteins, Non-Histone - physiology ; Cilia - metabolism ; DNA Repair ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; EF Hand Motifs ; Evolution, Molecular ; Genome ; Genomes ; Humans ; Life Sciences ; Protein Conformation ; Proteins ; Review ; Signal transduction ; Spindle Apparatus - genetics ; Vertebrates - metabolism
Es parte de: Cellular and molecular life sciences : CMLS, 2012-09, Vol.69 (18), p.2979-2997
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descripción: Centrins are small, highly conserved members of the EF-hand superfamily of calcium-binding proteins that are found throughout eukaryotes. They play a major role in ensuring the duplication and appropriate functioning of the ciliary basal bodies in ciliated cells. They have also been localised to the centrosome, which is the major microtubule organising centre in animal somatic cells. We describe the identification, cloning and characterisation of centrins in multiple eukaryotic species. Although centrins have been implicated in centriole biogenesis, recent results have indicated that centrosome duplication can, in fact, occur in the absence of centrins. We discuss these data and the non-centrosomal functions that are emerging for the centrins. In particular, we discuss the involvement of centrins in nucleotide excision repair, a process that repairs the DNA lesions that are induced primarily by ultraviolet irradiation. We discuss how centrin may be involved in these diverse processes and contribute to nuclear and cytoplasmic events.
Editor: Basel: SP Birkhäuser Verlag Basel
Idioma: Inglés

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Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance

Dantas, Tiago J. ; Daly, Owen M. ; Morrison, Ciaran G.

Basel: SP Birkhäuser Verlag Basel

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