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Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques

Klatt, Nichole R ; Canary, Lauren A ; Sun, Xiaoyong ; Vinton, Carol L ; Funderburg, Nicholas T ; Morcock, David R ; Quiñones, Mariam ; Deming, Clayton B ; Perkins, Molly ; Hazuda, Daria J ; Miller, Michael D ; Lederman, Michael M ; Segre, Julie A ; Lifson, Jeffrey D ; Haddad, Elias K ; Estes, Jacob D ; Brenchley, Jason M

The Journal of clinical investigation, 2013-02, Vol.123 (2), p.903-907 [Periódico revisado por pares]

United States: American Society for Clinical Investigation

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Título:
Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques
Autor: Klatt, Nichole R ; Canary, Lauren A ; Sun, Xiaoyong ; Vinton, Carol L ; Funderburg, Nicholas T ; Morcock, David R ; Quiñones, Mariam ; Deming, Clayton B ; Perkins, Molly ; Hazuda, Daria J ; Miller, Michael D ; Lederman, Michael M ; Segre, Julie A ; Lifson, Jeffrey D ; Haddad, Elias K ; Estes, Jacob D ; Brenchley, Jason M
Assuntos: Adjuvants, Immunologic - administration & dosage ; Animals ; Anti-Retroviral Agents - administration & dosage ; Antiviral agents ; Biomedical research ; Brief Report ; CD4-Positive T-Lymphocytes - immunology ; Cluster analysis ; Colon ; Combined Modality Therapy ; Cytokines ; Dietary Supplements ; Disease Models, Animal ; Feces ; Gastrointestinal system ; Gastrointestinal Tract - immunology ; Gene expression ; Health aspects ; HIV ; HIV Infections - immunology ; HIV Infections - therapy ; HIV patients ; Human immunodeficiency virus ; Humans ; Infections ; Inflammation ; Leukocytes ; Macaca ; Macaca nemestrina ; Microbiota ; Mortality ; Physiological aspects ; Physiology ; Prebiotics ; Probiotics ; Probiotics - administration & dosage ; Simian Acquired Immunodeficiency Syndrome - genetics ; Simian Acquired Immunodeficiency Syndrome - immunology ; Simian Acquired Immunodeficiency Syndrome - therapy ; Simian immunodeficiency virus ; Transcriptome
É parte de: The Journal of clinical investigation, 2013-02, Vol.123 (2), p.903-907
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Descrição: HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4+ T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.
Editor: United States: American Society for Clinical Investigation
Idioma: Inglês

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Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques

United States: American Society for Clinical Investigation

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