Idioma:

Sentinel node biopsy status is strongly predictive of survival in cutaneous melanoma: Extended follow-up of Oxford patients from 1998-2014

Thomson, David R ; Rughani, Milap G ; Kuo, Rachel ; Cassell, Oliver CS

Journal of plastic, reconstructive & aesthetic surgery, 2017-10, Vol.70 (10), p.1397-1403 [Periódico revisado por pares]

Netherlands: Elsevier Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Sentinel node biopsy status is strongly predictive of survival in cutaneous melanoma: Extended follow-up of Oxford patients from 1998-2014
Autor: Thomson, David R ; Rughani, Milap G ; Kuo, Rachel ; Cassell, Oliver CS
Assuntos: Adult ; Aged ; Aged, 80 and over ; Female ; Follow-up ; Follow-Up Studies ; Humans ; Lymphatic Metastasis - pathology ; Male ; Melanoma ; Melanoma - diagnosis ; Melanoma - mortality ; Melanoma - pathology ; Melanoma, Cutaneous Malignant ; Middle Aged ; Neoplasm Staging ; Plastic Surgery ; Predictive Value of Tests ; Prognosis ; Sentinel Lymph Node Biopsy - methods ; Sentinel Lymph Node Biopsy - statistics & numerical data ; Sentinel node biopsy ; Skin Neoplasms - diagnosis ; Skin Neoplasms - mortality ; Skin Neoplasms - pathology ; Survival ; Survival Analysis ; Tumor Burden ; United Kingdom - epidemiology
É parte de: Journal of plastic, reconstructive & aesthetic surgery, 2017-10, Vol.70 (10), p.1397-1403
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Abstract Introduction Sentinel lymph node biopsy (SLNB) is widely used as a key investigatory tool for cutaneous melanoma, with results incorporated into the latest AJCC staging guidelines. We present the results of our extended follow-up of sentinel lymph node biopsy for melanoma over a sixteen-year period. Methods Data were collected prospectively from June 1998 to December 2014 from a single tertiary skin cancer referral centre. Chi-squared analysis was used to analyse patient demographics and primary tumour pathology. Survival analysis was conducted using Cox regression models and Kaplan-Meier survival curves. Results Over a sixteen-year period 1,527 patients underwent SLNB in 1,609 basins, with 2,876 nodes harvested. 347 patients (23%) had a positive biopsy. The most common primary tumour sites for males was the back (32%); women had a significantly higher number of melanomas occurring on the lower and upper limbs (45% and 26% respectively) [all p<0.0001, Chi-squared]. Mean follow-up time was 4.9 years. Patients with a positive SLNB at diagnosis were significantly more likely to die from melanoma (subhazard ratio 5.59, p=0.000, 95% CI 3.59-8.69). Breslow thickness and ulceration were also significant predictors of melanoma-specific mortality. For patients with a primary Breslow >4.0mm ten-year disease free survival was 52% for SLNB negative and 26% for SLNB positive patients. For Breslow thicknesses of 2.01-4mm these values were 66% and 32% respectively. Conclusions Sentinel lymph node biopsy status is strongly predictive of survival across all thicknesses of primary cutaneous melanoma.
Editor: Netherlands: Elsevier Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Sentinel node biopsy status is strongly predictive of survival in cutaneous melanoma: Extended follow-up of Oxford patients from 1998-2014

Thomson, David R ; Rughani, Milap G ; Kuo, Rachel ; Cassell, Oliver CS

Netherlands: Elsevier Ltd

Buscando em bases de dados remotas. Favor aguardar.