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Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

Saunders, Kevin O ; Pardi, Norbert ; Parks, Robert ; Santra, Sampa ; Mu, Zekun ; Sutherland, Laura ; Scearce, Richard ; Barr, Maggie ; Eaton, Amanda ; Hernandez, Giovanna ; Goodman, Derrick ; Hogan, Michael J ; Tombacz, Istvan ; Gordon, David N ; Rountree, R Wes ; Wang, Yunfei ; Lewis, Mark G ; Pierson, Theodore C ; Barbosa, Chris ; Tam, Ying ; Shen, Xiaoying ; Ferrari, Guido ; Tomaras, Georgia D ; Montefiori, David C ; Weissman, Drew ; Haynes, Barton F

bioRxiv : the preprint server for biology, 2020-12

United States

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Título:
Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates
Autor: Saunders, Kevin O ; Pardi, Norbert ; Parks, Robert ; Santra, Sampa ; Mu, Zekun ; Sutherland, Laura ; Scearce, Richard ; Barr, Maggie ; Eaton, Amanda ; Hernandez, Giovanna ; Goodman, Derrick ; Hogan, Michael J ; Tombacz, Istvan ; Gordon, David N ; Rountree, R Wes ; Wang, Yunfei ; Lewis, Mark G ; Pierson, Theodore C ; Barbosa, Chris ; Tam, Ying ; Shen, Xiaoying ; Ferrari, Guido ; Tomaras, Georgia D ; Montefiori, David C ; Weissman, Drew ; Haynes, Barton F
É parte de: bioRxiv : the preprint server for biology, 2020-12
Descrição: Development of an effective AIDS vaccine remains a challenge. Nucleoside-modified mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of immunization against infectious diseases in preclinical studies, and are being tested for SARS-CoV-2 in humans. A critical question is how mRNA-LNP vaccine immunogenicity compares to that of traditional adjuvanted protein vaccines in primates. Here, we found that mRNA-LNP immunization compared to protein immunization elicited either the same or superior magnitude and breadth of HIV-1 Env-specific polyfunctional antibodies. Immunization with mRNA-LNP encoding Zika premembrane and envelope (prM-E) or HIV-1 Env gp160 induced durable neutralizing antibodies for at least 41 weeks. Doses of mRNA-LNP as low as 5 μg were immunogenic in macaques. Thus, mRNA-LNP can be used to rapidly generate single or multi-component vaccines, such as sequential vaccines needed to protect against HIV-1 infection. Such vaccines would be as or more immunogenic than adjuvanted recombinant protein vaccines in primates.
Editor: United States
Idioma: Inglês

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Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

United States

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