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Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

Li, Dapeng ; Martinez, David R ; Schäfer, Alexandra ; Chen, Haiyan ; Barr, Maggie ; Sutherland, Laura L ; Lee, Esther ; Parks, Robert ; Mielke, Dieter ; Edwards, Whitney ; Newman, Amanda ; Bock, Kevin W ; Minai, Mahnaz ; Nagata, Bianca M ; Gagne, Matthew ; Douek, Daniel C ; DeMarco, C Todd ; Denny, Thomas N ; Oguin, 3rd, Thomas H ; Brown, Alecia ; Rountree, Wes ; Wang, Yunfei ; Mansouri, Katayoun ; Edwards, Robert J ; Ferrari, Guido ; Sempowski, Gregory D ; Eaton, Amanda ; Tang, Juanjie ; Cain, Derek W ; Santra, Sampa ; Pardi, Norbert ; Weissman, Drew ; Tomai, Mark A ; Fox, Christopher B ; Moore, Ian N ; Andersen, Hanne ; Lewis, Mark G ; Golding, Hana ; Seder, Robert ; Khurana, Surender ; Baric, Ralph S ; Montefiori, David C ; Saunders, Kevin O ; Haynes, Barton F

bioRxiv : the preprint server for biology, 2022-02

United States

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Título:
Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine
Autor: Li, Dapeng ; Martinez, David R ; Schäfer, Alexandra ; Chen, Haiyan ; Barr, Maggie ; Sutherland, Laura L ; Lee, Esther ; Parks, Robert ; Mielke, Dieter ; Edwards, Whitney ; Newman, Amanda ; Bock, Kevin W ; Minai, Mahnaz ; Nagata, Bianca M ; Gagne, Matthew ; Douek, Daniel C ; DeMarco, C Todd ; Denny, Thomas N ; Oguin, 3rd, Thomas H ; Brown, Alecia ; Rountree, Wes ; Wang, Yunfei ; Mansouri, Katayoun ; Edwards, Robert J ; Ferrari, Guido ; Sempowski, Gregory D ; Eaton, Amanda ; Tang, Juanjie ; Cain, Derek W ; Santra, Sampa ; Pardi, Norbert ; Weissman, Drew ; Tomai, Mark A ; Fox, Christopher B ; Moore, Ian N ; Andersen, Hanne ; Lewis, Mark G ; Golding, Hana ; Seder, Robert ; Khurana, Surender ; Baric, Ralph S ; Montefiori, David C ; Saunders, Kevin O ; Haynes, Barton F
É parte de: bioRxiv : the preprint server for biology, 2022-02
Descrição: Coronavirus vaccines that are highly effective against SARS-CoV-2 variants are needed to control the current pandemic. We previously reported a receptor-binding domain (RBD) sortase A-conjugated ferritin nanoparticle (RBD-scNP) vaccine that induced neutralizing antibodies against SARS-CoV-2 and pre-emergent sarbecoviruses and protected monkeys from SARS-CoV-2 WA-1 infection. Here, we demonstrate SARS-CoV-2 RBD-scNP immunization induces potent neutralizing antibodies in non-human primates (NHPs) against all eight SARS-CoV-2 variants tested including the Beta, Delta, and Omicron variants. The Omicron variant was neutralized by RBD-scNP-induced serum antibodies with a mean of 10.6-fold reduction of ID50 titers compared to SARS-CoV-2 D614G. Immunization with RBD-scNPs protected NHPs from SARS-CoV-2 WA-1, Beta, and Delta variant challenge, and protected mice from challenges of SARS-CoV-2 Beta variant and two other heterologous sarbecoviruses. These results demonstrate the ability of RBD-scNPs to induce broad neutralization of SARS-CoV-2 variants and to protect NHPs and mice from multiple different SARS-related viruses. Such a vaccine could provide the needed immunity to slow the spread of and reduce disease caused by SARS-CoV-2 variants such as Delta and Omicron.
Editor: United States
Idioma: Inglês

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Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

United States

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