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Measurement of human tricarboxylic acid cycle rates during visual activation by (13)C magnetic resonance spectroscopy

Chhina, N ; Kuestermann, E ; Halliday, J ; Simpson, L J ; Macdonald, I A ; Bachelard, H S ; Morris, P G

Journal of neuroscience research, 2001-12, Vol.66 (5), p.737-746 [Periódico revisado por pares]

United States

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Título:
Measurement of human tricarboxylic acid cycle rates during visual activation by (13)C magnetic resonance spectroscopy
Autor: Chhina, N ; Kuestermann, E ; Halliday, J ; Simpson, L J ; Macdonald, I A ; Bachelard, H S ; Morris, P G
Assuntos: Adult ; Blood Glucose - physiology ; Carbon Radioisotopes ; Citric Acid Cycle - physiology ; Female ; Glucose - metabolism ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Oxidative Phosphorylation ; Photic Stimulation ; Radionuclide Imaging ; Visual Cortex - anatomy & histology ; Visual Cortex - diagnostic imaging ; Visual Perception - physiology
É parte de: Journal of neuroscience research, 2001-12, Vol.66 (5), p.737-746
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SourceType-Scholarly Journals-1
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Descrição: Measurement by (13)C magnetic resonance spectroscopy (MRS) of the incorporation of label from [1-(13)C] glucose, initially into C4 of glutamate, allows the regional tricarboxylic acid (TCA) cycle flux (F(TCA)) to be determined in the human brain. In this study, a direct (13)C MRS approach was used at 3T, with NOE enhancement and (1)H decoupling with WALTZ16, to determine basal F(TCA) in six volunteers. The values found in the visual cortex are similar to those reported in previous (13)C MRS studies, and consistent with PET measurements of the cerebral metabolic rate for glucose, CMRglc. In two preliminary activation studies using light emitting diode (LED) goggles flashing at 8 Hz, compared to darkness as control, increases in F(TCA) were found from 0.60 +/- 0.10 to 0.94 +/- 0.03 micromol/min/g (56%) and from 0.34 +/- 0.14 to 0.56 +/- 0.07 micromol/min/g (65%). These are upper estimates, but they are similar to the increases in CMRglc reported in PET studies, and strongly suggest, in contrast to these PET studies, that cerebral glucose is metabolized oxidatively, even during intense visual stimulation. This is supported by the observation that very little (13)C label is incorporated into C3 lactate, as would be expected if glucose were metabolized anaerobically. There is evidence for incorporation of glucose into cerebral glycogen, but this is a relatively minor component of cerebral glucose metabolism.
Editor: United States
Idioma: Inglês

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Measurement of human tricarboxylic acid cycle rates during visual activation by (13)C magnetic resonance spectroscopy

Chhina, N ; Kuestermann, E ; Halliday, J ; Simpson, L J ; Macdonald, I A ; Bachelard, H S ; Morris, P G

United States

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