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Acetylcholine releasing agents as cognition activators. Chemistry and pharmacology of a series of ureas

Thomas, Anthony J. ; Kester, Jeffrey A. ; Butler, Donald E. ; Hershenson, Fred M. ; Davis, Robert E. ; Marriott, John G. ; Schwarz, Roy D. ; Spencer, Carolyn J. ; Symons, James P. ; Moos, Walter H.

Bioorganic & medicinal chemistry letters, 1992-08, Vol.2 (8), p.855-860 [Periódico revisado por pares]

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Título:
Acetylcholine releasing agents as cognition activators. Chemistry and pharmacology of a series of ureas
Autor: Thomas, Anthony J. ; Kester, Jeffrey A. ; Butler, Donald E. ; Hershenson, Fred M. ; Davis, Robert E. ; Marriott, John G. ; Schwarz, Roy D. ; Spencer, Carolyn J. ; Symons, James P. ; Moos, Walter H.
Assuntos: Chemistry ; Chemistry, Medicinal ; Chemistry, Organic ; Life Sciences & Biomedicine ; Pharmacology & Pharmacy ; Physical Sciences ; Science & Technology
É parte de: Bioorganic & medicinal chemistry letters, 1992-08, Vol.2 (8), p.855-860
Descrição: We have sought to improve upon the activity of the well known AcCh-releasing agents, 4-aminopyridine and 3,4-diaminopyridine. This work has led to the discovery of a series of ureas with AcCh-releasing properties. From this series, compound 5 has emerged as a potent AcCh-releasing agent with promising in vivo activity. We have sought to improve upon the activity of the well known AcCH-releasing agents, 4-aminopyridine and 3,4-diaminopyridine. This work has led to the discovery of a series of ureas with AcCh-releasing properties. From this series, compound 5 has emerged as a potent AcCh-releasing agent with promising in vivo activity.
Editor: OXFORD: Elsevier Ltd
Idioma: Inglês

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