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Clinical application of CT and CT-guided percutaneous transthoracic needle biopsy in patients with indeterminate pulmonary nodules

Cardoso, Luciana Vargas ; Souza Júnior, Arthur Soares

Jornal brasileiro de pneumologia, 2014-07, Vol.40 (4), p.380-388 [Periódico revisado por pares]

Brazil: Sociedade Brasileira de Pneumologia e Tisiologia

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Título:
Clinical application of CT and CT-guided percutaneous transthoracic needle biopsy in patients with indeterminate pulmonary nodules
Autor: Cardoso, Luciana Vargas ; Souza Júnior, Arthur Soares
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy, Needle - methods ; Biópsia guiada por imagem ; Child ; Diagnosis, Differential ; Female ; Humans ; Image-Guided Biopsy - methods ; Lung - diagnostic imaging ; Lung - pathology ; Male ; Middle Aged ; Nódulo pulmonar solitário ; Original ; Radiography, Interventional - methods ; RESPIRATORY SYSTEM ; Retrospective Studies ; Solitary Pulmonary Nodule - classification ; Solitary Pulmonary Nodule - diagnosis ; Tomografia ; Tomography, X-Ray Computed ; Young Adult
É parte de: Jornal brasileiro de pneumologia, 2014-07, Vol.40 (4), p.380-388
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: To investigate the clinical application of CT and CT-guided percutaneous transthoracic needle biopsy (CT-PTNB) in patients with indeterminate pulmonary nodules (IPNs). We retrospectively studied 113 patients with PNs undergoing CT and CT-PTNB. Variables such as gender, age at diagnosis, smoking status, CT findings, and CT-PTNB techniques were analyzed. Data analysis was performed with the Student's t-test for independent samples the chi-square test, and normal approximation test for comparison of two proportions. Of the 113 patients studied, 68 (60.2%) were male and 78 (69%) were smokers. The diameter of malignant lesions ranged from 2.6 cm to 10.0 cm. Most of the IPNs (85%) were located in the peripheral region. The biopsied IPNs were found to be malignant in 88 patients (77.8%) and benign in 25 (22.2%). Adenocarcinoma was the most common malignant tumor, affecting older patients. The IPN diameter was significantly greater in patients with malignant PNs than in those with benign IPNs (p < 0.001). Having regular contour correlated significantly with an IPN being benign (p = 0.022), whereas spiculated IPNs and bosselated IPNs were more often malignant (in 50.7% and 28.7%, respectively). Homogeneous attenuation and necrosis were more common in patients with malignant lesions (51.9% and 26.9%, respectively) In our sample, CT and CT-PTNB were useful in distinguishing between malignant and benign IPNs. Advanced age and smoking were significantly associated with malignancy. Certain CT findings related to IPNs (larger diameter, spiculated borders, homogeneous attenuation, and necrosis) were associated with malignancy.
Editor: Brazil: Sociedade Brasileira de Pneumologia e Tisiologia
Idioma: Inglês;Português

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Clinical application of CT and CT-guided percutaneous transthoracic needle biopsy in patients with indeterminate pulmonary nodules

Cardoso, Luciana Vargas ; Souza Júnior, Arthur Soares

Brazil: Sociedade Brasileira de Pneumologia e Tisiologia

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