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Cross-reactive IgE antibody responses to tropomyosins from Ascaris lumbricoides and cockroach

Santos, Ana Beatriz R., PhD ; Rocha, Gutemberg M., MD ; Oliver, Constance, PhD ; Ferriani, Virgínia P.L., MD ; Lima, Rodrigo C., MD ; Palma, Mário S., PhD ; Sales, Valéria S.F., MD ; Aalberse, Rob C., PhD ; Chapman, Martin D., PhD ; Arruda, L. Karla, MD

Journal of allergy and clinical immunology, 2008-04, Vol.121 (4), p.1040-1046.e1 [Periódico revisado por pares]

New York, NY: Mosby, Inc

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Título:
Cross-reactive IgE antibody responses to tropomyosins from Ascaris lumbricoides and cockroach
Autor: Santos, Ana Beatriz R., PhD ; Rocha, Gutemberg M., MD ; Oliver, Constance, PhD ; Ferriani, Virgínia P.L., MD ; Lima, Rodrigo C., MD ; Palma, Mário S., PhD ; Sales, Valéria S.F., MD ; Aalberse, Rob C., PhD ; Chapman, Martin D., PhD ; Arruda, L. Karla, MD
Assuntos: Adolescent ; Adult ; Age ; Allergies ; allergy ; Allergy and Immunology ; Amino Acid Sequence ; Animals ; Ascaris lumbricoides ; Ascaris lumbricoides - chemistry ; Ascaris lumbricoides - immunology ; Asthma ; Asthma - immunology ; Asthma - metabolism ; Biological and medical sciences ; Child ; Child, Preschool ; Children & youth ; Cloning ; Cross Reactions ; Crustaceans ; Deoxyribonucleic acid ; DNA ; Dust ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Hypersensitivity - immunology ; Hypersensitivity - metabolism ; IgE cross-reactivity ; Immunoglobulin E - biosynthesis ; Immunoglobulin E - metabolism ; Immunopathology ; Infections ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Mollusks ; Parasites ; Periplaneta - chemistry ; Periplaneta - immunology ; Periplaneta americana ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Studies ; Tropical diseases ; Tropomyosin ; Tropomyosin - chemistry ; Tropomyosin - immunology ; Tropomyosin - metabolism ; Viral infections
É parte de: Journal of allergy and clinical immunology, 2008-04, Vol.121 (4), p.1040-1046.e1
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Background Evidence indicates that infection with Ascaris lumbricoides may promote development of allergy and asthma. Objective To study the role of tropomyosin, a pan-allergen in invertebrates, in IgE responses to A lumbricoides. Methods Recombinant A lumbricoides and Periplaneta americana tropomyosins were expressed in Pichia pastoris . Levels of IgE to tropomyosins from A lumbricoides and P americana were determined by chimeric ELISA in sera from 119 children living in a parasite-endemic area and 112 patients with cockroach allergy from the allergy clinics. Presence of tropomyosin in A lumbricoides larvae at L3 stage was evaluated by immunofluorescence using mAb 1A6, directed against mite tropomyosin. Molecular modeling of P americana and A lumbricoides tropomyosins was performed by using the MODELLER program. Results A lumbricoides tropomyosin showed 69% to 98% sequence identity to tropomyosins from other invertebrates. The predicted structure of A lumbricoides tropomyosin was similar to that of P americana tropomyosin and showed the characteristic coiled-coil structure. Strong correlation was found for IgE antibodies to tropomyosins from A lumbricoides and P americana in sera from children living in a parasite-endemic area and from patients with cockroach allergy. Larvae of A lumbricoides reacted strongly with mAb 1A6. Conclusion Tropomyosin induces IgE responses in A lumbricoides –infected children and in patients allergic to cockroach.
Editor: New York, NY: Mosby, Inc
Idioma: Inglês

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Cross-reactive IgE antibody responses to tropomyosins from Ascaris lumbricoides and cockroach

Santos, Ana Beatriz R., PhD ; Rocha, Gutemberg M., MD ; Oliver, Constance, PhD ; Ferriani, Virgínia P.L., MD ; Lima, Rodrigo C., MD ; Palma, Mário S., PhD ; Sales, Valéria S.F., MD ; Aalberse, Rob C., PhD ; Chapman, Martin D., PhD ; Arruda, L. Karla, MD

New York, NY: Mosby, Inc

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