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Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway

Wu, Yanglin ; He, Fan ; Zhang, Chenhui ; Zhang, Qin ; Su, Xinlin ; Zhu, Xu ; Liu, Ang ; Shi, Weidong ; Lin, Weifeng ; Jin, Zhongqin ; Yang, Huilin ; Lin, Jun

Journal of nanobiotechnology, 2021-06, Vol.19 (1), p.1-170, Article 170 [Periódico revisado por pares]

London: BioMed Central Ltd

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Título:
Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway
Autor: Wu, Yanglin ; He, Fan ; Zhang, Chenhui ; Zhang, Qin ; Su, Xinlin ; Zhu, Xu ; Liu, Ang ; Shi, Weidong ; Lin, Weifeng ; Jin, Zhongqin ; Yang, Huilin ; Lin, Jun
Assuntos: Acetic acid ; Antibiotics ; Bacteria ; Biomedical materials ; Bone turnover ; Butyrate ; Care and treatment ; Cell receptors ; Cellular signal transduction ; Complications and side effects ; Discriminant analysis ; Dysbacteriosis ; Enzymes ; Fatty acids ; Fecal microflora ; Feces ; Fractures ; GPR109A ; Gut microbiota ; Health aspects ; Homeostasis ; Inflammasomes ; Inflammation ; Inflammatory osteolysis ; Intestinal microflora ; Joint replacement ; Melatonin ; Metabolism ; Metabolites ; Metagenomics ; Microbiota ; Nanoparticles ; NLRP3 inflammasome ; Osteolysis ; Physiological aspects ; Physiology ; Propionic acid ; Prostheses ; Proteins ; Public health ; Relative abundance ; rRNA 16S ; Signal transduction ; Supplements ; Titanium ; Titanium products ; Transplantation ; Transplants & implants
É parte de: Journal of nanobiotechnology, 2021-06, Vol.19 (1), p.1-170, Article 170
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SourceType-Scholarly Journals-1
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Descrição: Inflammatory osteolysis after total joint replacement (TJR) may cause implant failure, periprosthetic fractures, and be a severe threat to global public health. Our previous studies demonstrated that melatonin had a therapeutic effect on wear-particles induced osteolysis. Gut microbiota is closely related to bone homeostasis, and has been proven to be affected by melatonin. However, whether melatonin could play its anti-osteolysis effects through reprogramming gut microbiota remains elusive. Here, we demonstrated that melatonin could alleviate Ti-particles induced osteolysis, while this therapeutic effect was blocked by antibiotic cocktail treatment. Interestingly, transplantation of fecal microbiota from mice treated with melatonin reappeared the same beneficial effect. Analysis of the 16S rRNA revealed that melatonin could reverse dysbacteriosis triggered by osteolysis, and elevate the relative abundance of some short chain fatty acid (SCFA) producing bacteria. Moreover, butyrate was enriched by exogenous melatonin administration, while acetate and propionate did not show an evident difference. This was consistent with the results of the metagenomic approach (PICRUSt2) analysis, which revealed a general increase in the synthetic enzymes of butyrate. More importantly, direct supplementation of butyrate could also recapitulate the anti-osteolysis effect of melatonin. Further analysis identified that butyrate alleviated osteolysis via activating its receptor GPR109A, and thus to suppress the activation of NLRP3 inflammasome triggered by Ti-particles. Taken together, our results suggested that the benefits of melatonin mainly depend on the ability of modulating gut microbiota and regulating butyrate production.
Editor: London: BioMed Central Ltd
Idioma: Inglês

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Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway

Wu, Yanglin ; He, Fan ; Zhang, Chenhui ; Zhang, Qin ; Su, Xinlin ; Zhu, Xu ; Liu, Ang ; Shi, Weidong ; Lin, Weifeng ; Jin, Zhongqin ; Yang, Huilin ; Lin, Jun

London: BioMed Central Ltd

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