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Neutrophils as effectors of vascular inflammation

Gómez‐Moreno, Diego ; Adrover, José María ; Hidalgo, Andrés

European journal of clinical investigation, 2018-11, Vol.48 (S2), p.e12940-n/a [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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Título:
Neutrophils as effectors of vascular inflammation
Autor: Gómez‐Moreno, Diego ; Adrover, José María ; Hidalgo, Andrés
Assuntos: adrenergic signalling ; Anemia, Sickle Cell - physiopathology ; Animals ; Atherosclerosis - physiopathology ; Blood Platelets - physiology ; Blood vessels ; cardiovascular disease ; Cardiovascular diseases ; Catecholamines ; Cell activation ; Deoxyribonucleic acid ; Disease Models, Animal ; DNA ; Endothelium, Vascular - physiology ; Extracellular Traps - physiology ; Humans ; Imaging techniques ; Inflammation ; Leukocytes ; Leukocytes (neutrophilic) ; Mice ; neutrophil extracellular traps ; Neutrophil Infiltration - physiology ; Neutrophils ; Neutrophils - physiology ; Platelets ; Reactive Oxygen Species - metabolism ; Reperfusion Injury - physiopathology ; Signal Transduction - physiology ; vascular inflammation ; Vasculitis - physiopathology ; Venous Thrombosis - physiopathology
É parte de: European journal of clinical investigation, 2018-11, Vol.48 (S2), p.e12940-n/a
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Vascular inflammation underlies most forms of cardiovascular disease, which remains a prevalent cause of death among the global population. Advances in the biology of neutrophils, as well as insights into their dynamics in tissues, have revealed that these cells are prominent drivers of vascular inflammation though derailed activation within blood vessels. The development of powerful imaging techniques, as well as identification of cells and molecules that regulate their activation within vessels, including platelets and catecholamines, has been instrumental to better understand the mechanisms through which neutrophils protect or damage the organism. Other advances in our understanding of how these leucocytes exert detrimental functions on neighbouring cells, including the formation of DNA‐based extracellular traps, constitute milestones in defining neutrophil‐driven inflammation. Here, we review emerging mechanisms that regulate intravascular activation and effector functions of neutrophils, and discuss specific pathologies in which these processes are relevant. We argue that identification of pathways and mechanisms specifically engaged within the vasculature may provide effective therapies to treat this prevalent group of pathologies.
Editor: England: Blackwell Publishing Ltd
Idioma: Inglês

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Neutrophils as effectors of vascular inflammation

Gómez‐Moreno, Diego ; Adrover, José María ; Hidalgo, Andrés

England: Blackwell Publishing Ltd

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