Idioma:

Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia

Rothenberg-Thurley, Maja ; Amler, Susanne ; Goerlich, Dennis ; Köhnke, Thomas ; Konstandin, Nikola P ; Schneider, Stephanie ; Sauerland, Maria C ; Herold, Tobias ; Hubmann, Max ; Ksienzyk, Bianka ; Zellmeier, Evelyn ; Bohlander, Stefan K ; Subklewe, Marion ; Faldum, Andreas ; Hiddemann, Wolfgang ; Braess, Jan ; Spiekermann, Karsten ; Metzeler, Klaus H

Leukemia, 2018-07, Vol.32 (7), p.1598-1608 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia
Autor: Rothenberg-Thurley, Maja ; Amler, Susanne ; Goerlich, Dennis ; Köhnke, Thomas ; Konstandin, Nikola P ; Schneider, Stephanie ; Sauerland, Maria C ; Herold, Tobias ; Hubmann, Max ; Ksienzyk, Bianka ; Zellmeier, Evelyn ; Bohlander, Stefan K ; Subklewe, Marion ; Faldum, Andreas ; Hiddemann, Wolfgang ; Braess, Jan ; Spiekermann, Karsten ; Metzeler, Klaus H
Assuntos: Acute myelocytic leukemia ; Acute myeloid leukemia ; Adult ; Aged ; Aged, 80 and over ; Biomarkers ; Biomarkers, Tumor ; Bone Marrow - pathology ; Cancer genetics ; Cancer treatment ; Cell proliferation ; Chemotherapy ; Clonal Evolution - genetics ; Cloning ; Combined Modality Therapy ; Development and progression ; DNA (Cytosine-5-)-Methyltransferases - genetics ; Elderly ; Elderly patients ; Female ; Gene mutation ; Gene mutations ; Genes ; Genetic analysis ; Genetic aspects ; Genetic research ; Geriatrics ; Humans ; Leukemia ; Leukemia, Myeloid, Acute - drug therapy ; Leukemia, Myeloid, Acute - genetics ; Leukemia, Myeloid, Acute - pathology ; Male ; Methyltransferases ; Middle Aged ; Mutation ; Myeloid leukemia ; Neoplasm, Residual - pathology ; Older people ; Patients ; Proportional Hazards Models ; Recurrence ; Recurrence (Disease) ; Remission ; Remission (Medicine) ; Remission Induction ; Risk Assessment ; Risk factors ; Stem cell transplantation ; Stem cells ; Surgery ; Survival ; Transplantation ; Treatment Outcome ; Young Adult
É parte de: Leukemia, 2018-07, Vol.32 (7), p.1598-1608
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Some patients with acute myeloid leukemia (AML) who are in complete remission after induction chemotherapy harbor persisting pre-leukemic clones, carrying a subset of leukemia-associated somatic mutations. There is conflicting evidence on the prognostic relevance of these clones for AML relapse. Here, we characterized paired pre-treatment and remission samples from 126 AML patients for mutations in 68 leukemia-associated genes. Fifty patients (40%) retained ≥1 mutation during remission at a VAF of ≥2%. Mutation persistence was most frequent in DNMT3A (65% of patients with mutations at diagnosis), SRSF2 (64%), TET2 (55%), and ASXL1 (46%), and significantly associated with older age (p < 0.0001) and, in multivariate analyses adjusting for age, genetic risk, and allogeneic transplantation, with inferior relapse-free survival (hazard ratio (HR), 2.34; p = 0.0039) and overall survival (HR, 2.14; p = 0.036). Patients with persisting mutations had a higher cumulative incidence of relapse before, but not after allogeneic stem cell transplantation. Our work underlines the relevance of mutation persistence during first remission as a novel risk factor in AML. Persistence of pre-leukemic clones may contribute to the inferior outcome of elderly AML patients. Allogeneic transplantation abrogated the increased relapse risk associated with persisting pre-leukemic clones, suggesting that mutation persistence may guide post-remission treatment.
Editor: England: Nature Publishing Group
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.