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Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

Dixon, R. A. F ; Diehl, R. E ; Opas, E ; Rands, E ; Vickers, P. J ; Evans, J. F ; Gillard, J. W ; Miller, D. K

Nature (London), 1990-01, Vol.343 (6255), p.282-284 [Periódico revisado por pares]

London: Nature Publishing

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Título:
Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
Autor: Dixon, R. A. F ; Diehl, R. E ; Opas, E ; Rands, E ; Vickers, P. J ; Evans, J. F ; Gillard, J. W ; Miller, D. K
Assuntos: 5-Lipoxygenase-Activating Proteins ; Abnormalities ; Amino Acid Sequence ; Analytical, structural and metabolic biochemistry ; Animals ; Arachidonate 5-lipoxygenase ; Arachidonate 5-Lipoxygenase - metabolism ; Arachidonate Lipoxygenases - metabolism ; Arachidonic acid ; Arthritis ; Asthma ; Base Sequence ; Biochemistry ; Biological activity ; Biological and medical sciences ; Bone cancer ; Carrier Proteins ; Cell Line ; Cellular biology ; Cloning ; Complementary DNA ; Enzymes ; Fatty acids ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; genes ; Humans ; Inflammation ; Laboratories ; Leukocytes ; Leukotrienes ; Leukotrienes - biosynthesis ; Lipids ; Lipoxygenase ; man ; Medical research ; Membrane proteins ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Metabolites ; Molecular Sequence Data ; Molecules ; Neutrophils ; Osteosarcoma ; Other biological molecules ; Physiological aspects ; Protein biosynthesis ; Proteins ; Rats ; Sequence Homology, Nucleic Acid ; Synthesis ; Transfection
É parte de: Nature (London), 1990-01, Vol.343 (6255), p.282-284
Notas: ObjectType-Article-1
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Descrição: Leukotrienes, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory responses, including asthma, arthritis and psoriasis. Recently a compound, MK-886, has been described that blocks the synthesis of leukotrienes in intact activated leukocytes, but has little or no effect on enzymes involved in leukotriene synthesis, including 5-lipoxygenase, in cell-free systems. A membrane protein with a high affinity for MK-886 and possibly representing the cellular target for MK-886 has been isolated from rat and human leukocytes. Here, we report the isolation of a complementary DNA clone encoding the MK-886-binding protein. We also demonstrate that the expression of both the MK-886-binding protein and 5-lipoxygenase is necessary for leukotriene synthesis in intact cells. Because the MK-886-binding protein seems to play a part in activating this enzyme in cells, it is termed the five-lipoxygenase activating protein (FLAP).
Editor: London: Nature Publishing
Idioma: Inglês

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Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

Dixon, R. A. F ; Diehl, R. E ; Opas, E ; Rands, E ; Vickers, P. J ; Evans, J. F ; Gillard, J. W ; Miller, D. K

London: Nature Publishing

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