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Peroxiredoxins are conserved markers of circadian rhythms

EDGAR, Rachel S ; GREEN, Edward W ; MAYWOOD, Elizabeth S ; HASTINGS, Michael H ; BALIGA, Nitin S ; MERROW, Martha ; MILLAR, Andrew J ; JOHNSON, Carl H ; KYRIACOU, Charalambos P ; O'NEILL, John S ; REDDY, Akhilesh B ; YUWEI ZHAO ; OOIJEN, Gerben Van ; OLMEDO, Maria ; XIMING QIN ; YAO XU ; MIN PAN ; VALEKUNJA, Utham K ; FEENEY, Kevin A

Nature (London), 2012-05, Vol.485 (7399), p.459-464 [Periódico revisado por pares]

London: Nature Publishing Group

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Título:
Peroxiredoxins are conserved markers of circadian rhythms
Autor: EDGAR, Rachel S ; GREEN, Edward W ; MAYWOOD, Elizabeth S ; HASTINGS, Michael H ; BALIGA, Nitin S ; MERROW, Martha ; MILLAR, Andrew J ; JOHNSON, Carl H ; KYRIACOU, Charalambos P ; O'NEILL, John S ; REDDY, Akhilesh B ; YUWEI ZHAO ; OOIJEN, Gerben Van ; OLMEDO, Maria ; XIMING QIN ; YAO XU ; MIN PAN ; VALEKUNJA, Utham K ; FEENEY, Kevin A
Assuntos: Amino Acid Sequence ; Animals ; Antioxidants ; Archaea ; Archaea - metabolism ; Bacteria ; Bacteria - metabolism ; Bacterial proteins ; Biological and medical sciences ; Biological evolution ; Biological markers ; Biomarkers - metabolism ; Catalytic Domain ; Circadian Clocks - genetics ; Circadian Clocks - physiology ; Circadian rhythm ; Circadian Rhythm - genetics ; Circadian Rhythm - physiology ; Circadian rhythms ; Conserved Sequence ; Eukaryotic Cells - metabolism ; Evolution, Molecular ; Feedback, Physiological ; Fundamental and applied biological sciences. Psychology ; Genetic aspects ; Genetics of eukaryotes. Biological and molecular evolution ; Homeostasis ; Humans ; Identification and classification ; Insects ; Light ; Models, Biological ; Molecular Sequence Data ; Organisms ; Oxidation-Reduction ; Peroxiredoxins - chemistry ; Peroxiredoxins - metabolism ; Phylogenetics ; Phylogeny ; Prokaryotes ; Prokaryotic Cells - metabolism ; Properties ; Protein Biosynthesis ; Transcription, Genetic ; Trees
É parte de: Nature (London), 2012-05, Vol.485 (7399), p.459-464
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SourceType-Scholarly Journals-1
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These authors contributed equally to this work
Descrição: Cellular life emerged ∼3.7 billion years ago. With scant exception, terrestrial organisms have evolved under predictable daily cycles owing to the Earth's rotation. The advantage conferred on organisms that anticipate such environmental cycles has driven the evolution of endogenous circadian rhythms that tune internal physiology to external conditions. The molecular phylogeny of mechanisms driving these rhythms has been difficult to dissect because identified clock genes and proteins are not conserved across the domains of life: Bacteria, Archaea and Eukaryota. Here we show that oxidation-reduction cycles of peroxiredoxin proteins constitute a universal marker for circadian rhythms in all domains of life, by characterizing their oscillations in a variety of model organisms. Furthermore, we explore the interconnectivity between these metabolic cycles and transcription-translation feedback loops of the clockwork in each system. Our results suggest an intimate co-evolution of cellular timekeeping with redox homeostatic mechanisms after the Great Oxidation Event ∼2.5 billion years ago.
Editor: London: Nature Publishing Group
Idioma: Inglês

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Peroxiredoxins are conserved markers of circadian rhythms

London: Nature Publishing Group

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