skip to main content
Visitante
Meu Espaço
Minha Conta
Sair
Identificação
This feature requires javascript
Tags
Revistas Eletrônicas (eJournals)
Livros Eletrônicos (eBooks)
Bases de Dados
Bibliotecas USP
Ajuda
Ajuda
Idioma:
Inglês
Espanhol
Português
This feature required javascript
This feature requires javascript
Primo Advanced Search
Busca Geral
Busca Geral
Acervo Físico
Acervo Físico
Produção Intelectual da USP
Produção USP
Primo Advanced Search Query Term
Input search text:
Show Results with:
criteria input
Qualquer
Show Results with:
Qualquer
Primo Advanced Search prefilters
Tipo de material:
criteria input
Todos os itens
Busca Geral
Busca Simples
This feature requires javascript
In vitro effects of propofol on rat myocardium
RIOU, B ; BESSE, S ; LECARPENTIER, Y ; VIARS, P
Anesthesiology (Philadelphia), 1992-04, Vol.76 (4), p.609-616
[Periódico revisado por pares]
Hagerstown, MD: Lippincott
Texto completo disponível
Citações
Citado por
Exibir Online
Detalhes
Resenhas & Tags
Mais Opções
Nº de Citações
This feature requires javascript
Enviar para
Adicionar ao Meu Espaço
Remover do Meu Espaço
E-mail (máximo 30 registros por vez)
Imprimir
Link permanente
Referência
EasyBib
EndNote
RefWorks
del.icio.us
Exportar RIS
Exportar BibTeX
This feature requires javascript
Título:
In vitro effects of propofol on rat myocardium
Autor:
RIOU, B
;
BESSE, S
;
LECARPENTIER, Y
;
VIARS, P
Assuntos:
Anesthetics. Neuromuscular blocking agents
;
Animals
;
Biological and medical sciences
;
Heart
- drug effects
;
Hydrogen-Ion Concentration
;
Life Sciences
;
Male
;
Medical sciences
;
Myocardial Contraction - drug effects
;
Neuropharmacology
;
Pharmacology. Drug treatments
;
Propofol - pharmacology
;
Rats
;
Rats, Inbred Strains
É parte de:
Anesthesiology (Philadelphia), 1992-04, Vol.76 (4), p.609-616
Notas:
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição:
Propofol is a short-acting intravenous induction agent that induces cardiovascular depression. However, the effects of propofol on intrinsic myocardial contractility remain debatable. Thus, we studied the effects of three concentrations of propofol (1, 3, and 10 micrograms.ml-1, respectively) and its solvent on the mechanics and energetics of isolated rat left ventricular papillary muscles. Propofol and its solvent did not induce any significant inotropic effect as shown by the lack of significant changes in maximum unloaded shortening velocity and in active isometric force. Nevertheless, propofol induced a slight decrease in isometric force (92 +/- 6%, 95 +/- 5%, and 95 +/- 4%, respectively, all P less than 0.01) under certain experimental conditions (i.e., after isometric stabilization). Using various afterloaded twitches, the peak power output and the curvature of the force-velocity curve were calculated. Propofol and its solvent did not significantly modify these two energetic parameters, indicating that it did not change myothermal economy and cross-bridge kinetics. Propofol impaired isotonic relaxation, suggesting that it decreased calcium uptake by the sarcoplasmic reticulum, whereas its solvent alone did not. However, alteration of sarcoplasmic reticulum function was moderate, since postrest potentiation and postrest recovery were unmodified after propofol. It was concluded that propofol induces moderate changes on intrinsic myocardial contractility. These results suggest that cardiovascular depression observed with propofol in vivo is not related to intrinsic myocardial depression.
Editor:
Hagerstown, MD: Lippincott
Idioma:
Inglês
Links
View record in Pascal Francis
View this record in MEDLINE/PubMed
View record in HAL
This feature requires javascript
This feature requires javascript
Voltar para lista de resultados
Anterior
Resultado
9
Avançar
This feature requires javascript
This feature requires javascript
Buscando em bases de dados remotas. Favor aguardar.
Buscando por
em
scope:(USP_VIDEOS),scope:("PRIMO"),scope:(USP_FISICO),scope:(USP_EREVISTAS),scope:(USP),scope:(USP_EBOOKS),scope:(USP_PRODUCAO),primo_central_multiple_fe
Mostrar o que foi encontrado até o momento
This feature requires javascript
This feature requires javascript