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Effects of estrogen replacement on plasma lipoproteins and apolipoproteins in postmenopausal, dyslipidemic women

Granfone, Antonio ; Campos, Hannia ; McNamara, Judith R. ; Schaefer, Mary M. ; Lamon-Fava, Stefania ; Ordovas, Jose M. ; Schaefer, Ernst J.

Metabolism, clinical and experimental, 1992-11, Vol.41 (11), p.1193-1198 [Periódico revisado por pares]

PHILADELPHIA: Elsevier Inc

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Título:
Effects of estrogen replacement on plasma lipoproteins and apolipoproteins in postmenopausal, dyslipidemic women
Autor: Granfone, Antonio ; Campos, Hannia ; McNamara, Judith R. ; Schaefer, Mary M. ; Lamon-Fava, Stefania ; Ordovas, Jose M. ; Schaefer, Ernst J.
Assuntos: Aged ; Apolipoproteins - blood ; Biological and medical sciences ; BIOLOGICAL RHYTHMS ; BLOOD PLASMA ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cholesterol, VLDL - blood ; DISORDERS ; Endocrinology & Metabolism ; ESTRADIOL ; Estrogen Replacement Therapy ; ESTROGENOS ; Female ; FEMME ; GROSSEUR DES PARTICULES ; HISTERECTOMIA ; Hormones. Endocrine system ; Humans ; HYSTERECTOMIE ; HYSTERECTOMY ; Life Sciences & Biomedicine ; LIPID METABOLISM ; Lipids - blood ; LIPOPROTEINAS ; LIPOPROTEINE ; LIPOPROTEINS ; Lipoproteins - blood ; Medical sciences ; MENOPAUSE ; Menopause - blood ; METABOLISME DES LIPIDES ; METABOLISMO DE LIPIDOS ; Middle Aged ; MUJERES ; OESTROGENE ; OESTROGENS ; PARTICLE SIZE ; Pharmacology. Drug treatments ; PLASMA SANGUIN ; PLASMA SANGUINEO ; RITMOS BIOLOGICOS ; RYTHME BIOLOGIQUE ; Science & Technology ; TAMANO DE LA PARTICULA ; TERAPIA ; THERAPEUTIQUE ; THERAPY ; TRASTORNOS ; TROUBLE ; WOMEN
É parte de: Metabolism, clinical and experimental, 1992-11, Vol.41 (11), p.1193-1198
Notas: 9324971
S30
Medline
NIH RePORTER
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: The effects of oral estrogen replacement (ethinyl estradiol 0.02 mg/d) on plasma triglyceride, total cholesterol, very-low-density lipoprotein (VLDL) cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and apolipoprotein (apo) A-I and B levels and LDL particle size were assessed in 20 postmenopausal women with a previous hysterectomy and various forms of dyslipidemia (LDL cholesterol ≥ 4.14 mmol/L [160 mg/dL] and/or HDL cholesterol ≤ 1.03 mmol/L [40 mg/dL]). All subjects were studied while on a standard cholesterol-lowering diet, and were sampled in the fasting state before beginning estrogen therapy and after a mean of 13 weeks of estrogen therapy. Lipids were measured by standardized enzymatic techniques, apos were measured by enzyme-linked immunoassays, and LDL particle size was measured by gradient gel electrophoresis. Mean values for plasma lipid parameters (mmol/L) at baseline and during estrogen replacement were as follows: triglyceride, 2.11 and 2.75 (30% increase); total cholesterol, 7.45 and 6.52 (13% decrease); VLDL cholesterol, 1.09 and 1.22 (12% increase); LDL cholesterol, 5.09 and 3.70 (27% decrease); and HDL cholesterol, 1.27 and 1.58 (24% increase). Mean values for apo A-I were 163 and 254 mg/dL (56% increase), and for apo B they were 170 and 148 mg/dL (13% decrease). The LDL particle score was 4.09 and 4.52 (11% smaller). Changes in all parameters were statistically significant ( P = .05) except for VLDL cholesterol. These data indicate that estrogen replacement is effective in decreasing LDL cholesterol and apo B concentrations and increasing HDL cholesterol and apo A-I concentrations in dyslipidemic postmenopausal women, but it should not be used in patients with baseline fasting triglyceride levels higher than 2.82 mmol/L (250 mg/dL) unless it is accompanied by a progestin. Our data indicate that this form of estrogen replacement could lower the risk of coronary artery disease (CAD) by more than 50% in these women, based on favorable alterations in plasma lipoproteins.
Editor: PHILADELPHIA: Elsevier Inc
Idioma: Inglês

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Effects of estrogen replacement on plasma lipoproteins and apolipoproteins in postmenopausal, dyslipidemic women

Granfone, Antonio ; Campos, Hannia ; McNamara, Judith R. ; Schaefer, Mary M. ; Lamon-Fava, Stefania ; Ordovas, Jose M. ; Schaefer, Ernst J.

PHILADELPHIA: Elsevier Inc

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