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R loops: new modulators of genome dynamics and function
Santos-Pereira, José M ; Aguilera, Andrés
Nature reviews. Genetics, 2015-10, Vol.16 (10), p.583-597
[Periódico revisado por pares]
England: Nature Publishing Group
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Título:
R loops: new modulators of genome dynamics and function
Autor:
Santos-
Pereira
, José
M
;
Aguilera, Andrés
Assuntos:
Chromatin - metabolism
;
DNA - chemistry
;
DNA - genetics
;
DNA - metabolism
;
DNA, Single-Stranded - metabolism
;
Genomic Instability
;
Humans
;
Neoplasms - genetics
;
Neurodegenerative Diseases - genetics
;
Nucleic Acid Conformation
;
RNA - chemistry
;
RNA - genetics
;
RNA - metabolism
;
RNA Polymerase II - metabolism
;
Transcription, Genetic
É parte de:
Nature reviews. Genetics, 2015-10, Vol.16 (10), p.583-597
Notas:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
Descrição:
R loops are nucleic acid structures composed of an RNA-DNA hybrid and a displaced single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the genome and have greater physiological relevance, including roles in transcription and chromatin structure, than was previously predicted. Importantly, however, R loops are also a major threat to genome stability. For this reason, several DNA and RNA metabolism factors prevent R-loop formation in cells. Dysfunction of these factors causes R-loop accumulation, which leads to replication stress, genome instability, chromatin alterations or gene silencing, phenomena that are frequently associated with cancer and a number of genetic diseases. We review the current knowledge of the mechanisms controlling R loops and their putative relationship with disease.
Editor:
England: Nature Publishing Group
Idioma:
Inglês
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